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Model for melting of confined DNA

Werner, E.; Reiter-Schad, Michaela LU ; Ambjörnsson, Tobias LU and Mehlig, B. (2015) In Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)2001-01-01+01:002016-01-01+01:00 91(6).
Abstract
When DNA molecules are heated they denature. This occurs locally so that loops of molten single DNA strands form, connected by intact double-stranded DNA pieces. The properties of this "melting" transition have been intensively investigated. Recently there has been a surge of interest in this question, in part caused by experiments determining the properties of partially bound DNA confined to nanochannels. But how does such confinement affect the melting transition? To answer this question we introduce and solve a model predicting how confinement affects the melting transition for a simple model system by first disregarding the effect of self-avoidance. We find that the transition is smoother for narrower channels. By means of Monte Carlo... (More)
When DNA molecules are heated they denature. This occurs locally so that loops of molten single DNA strands form, connected by intact double-stranded DNA pieces. The properties of this "melting" transition have been intensively investigated. Recently there has been a surge of interest in this question, in part caused by experiments determining the properties of partially bound DNA confined to nanochannels. But how does such confinement affect the melting transition? To answer this question we introduce and solve a model predicting how confinement affects the melting transition for a simple model system by first disregarding the effect of self-avoidance. We find that the transition is smoother for narrower channels. By means of Monte Carlo simulations we then show that a model incorporating self-avoidance shows qualitatively the same behavior and that the effect of confinement is stronger than in the ideal case. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)2001-01-01+01:002016-01-01+01:00
volume
91
issue
6
publisher
American Physical Society
external identifiers
  • wos:000356929400002
  • pmid:26172649
  • scopus:84937019974
ISSN
1539-3755
DOI
10.1103/PhysRevE.91.060702
language
English
LU publication?
yes
id
b7f0e4b2-d31b-4095-b634-dacba8195c33 (old id 7587785)
date added to LUP
2015-07-23 08:28:18
date last changed
2017-08-13 03:16:58
@article{b7f0e4b2-d31b-4095-b634-dacba8195c33,
  abstract     = {When DNA molecules are heated they denature. This occurs locally so that loops of molten single DNA strands form, connected by intact double-stranded DNA pieces. The properties of this "melting" transition have been intensively investigated. Recently there has been a surge of interest in this question, in part caused by experiments determining the properties of partially bound DNA confined to nanochannels. But how does such confinement affect the melting transition? To answer this question we introduce and solve a model predicting how confinement affects the melting transition for a simple model system by first disregarding the effect of self-avoidance. We find that the transition is smoother for narrower channels. By means of Monte Carlo simulations we then show that a model incorporating self-avoidance shows qualitatively the same behavior and that the effect of confinement is stronger than in the ideal case.},
  articleno    = {060702},
  author       = {Werner, E. and Reiter-Schad, Michaela and Ambjörnsson, Tobias and Mehlig, B.},
  issn         = {1539-3755},
  language     = {eng},
  number       = {6},
  publisher    = {American Physical Society},
  series       = {Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)2001-01-01+01:002016-01-01+01:00},
  title        = {Model for melting of confined DNA},
  url          = {http://dx.doi.org/10.1103/PhysRevE.91.060702},
  volume       = {91},
  year         = {2015},
}