Fria radikaler och sjuka proteiner - bovarna bakom Parkinsons sjukdom?[Free radicals and ailing proteins - the culprits behind Parkinson’s disease?]
(2003) In Läkartidningen 100(15). p.6-1329- Abstract
- Parkinson’s disease is one of the most common neurodegenerative diseases, and affects approximately 1% of the population over 65 years of age. Many different insults appear to be involved in the etiology of the disease, among them environmental toxins and mitochondrial dysfunction. During the past five years, mutations in five different genes have been linked to rare, familial forms of Parkinson’s disease. One of the mutated proteins, a-synuclein is normally implicated in synaptic plasticity and vesicle function. Dysfunction of this protein might lead to increased cytoplasmic dopamine
levels. Since cytoplasmic dopamine is readily
prone to autooxidation and enzymatic degradation - processes which generate reactive oxygen... (More) - Parkinson’s disease is one of the most common neurodegenerative diseases, and affects approximately 1% of the population over 65 years of age. Many different insults appear to be involved in the etiology of the disease, among them environmental toxins and mitochondrial dysfunction. During the past five years, mutations in five different genes have been linked to rare, familial forms of Parkinson’s disease. One of the mutated proteins, a-synuclein is normally implicated in synaptic plasticity and vesicle function. Dysfunction of this protein might lead to increased cytoplasmic dopamine
levels. Since cytoplasmic dopamine is readily
prone to autooxidation and enzymatic degradation - processes which generate reactive oxygen species - failure to properly store dopamine into vesicles might lead to oxidative stress. Indeed, nigral tissue from idiopathic Parkinson’s disease patients shows signs of oxidative damage. In this article we propose that dopamine-induced oxidative stress might be a common final pathway in the pathogenesis of the disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/114120
- author
- Smith, Ruben LU ; Lotharius, Julie LU and Brundin, Patrik LU
- organization
- alternative title
- Free radicals and ailing proteins- the culprits behind Parkinson’s disease?
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 100
- issue
- 15
- pages
- 6 - 1329
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:0344392124
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 7592ff0c-a7ef-4218-93dc-c3d9cd08f517 (old id 114120)
- alternative location
- http://ltarkiv.lakartidningen.se/artNo26514
- date added to LUP
- 2016-04-01 15:47:00
- date last changed
- 2022-02-20 01:03:15
@article{7592ff0c-a7ef-4218-93dc-c3d9cd08f517,
abstract = {{Parkinson’s disease is one of the most common neurodegenerative diseases, and affects approximately 1% of the population over 65 years of age. Many different insults appear to be involved in the etiology of the disease, among them environmental toxins and mitochondrial dysfunction. During the past five years, mutations in five different genes have been linked to rare, familial forms of Parkinson’s disease. One of the mutated proteins, a-synuclein is normally implicated in synaptic plasticity and vesicle function. Dysfunction of this protein might lead to increased cytoplasmic dopamine<br/><br>
levels. Since cytoplasmic dopamine is readily<br/><br>
prone to autooxidation and enzymatic degradation - processes which generate reactive oxygen species - failure to properly store dopamine into vesicles might lead to oxidative stress. Indeed, nigral tissue from idiopathic Parkinson’s disease patients shows signs of oxidative damage. In this article we propose that dopamine-induced oxidative stress might be a common final pathway in the pathogenesis of the disease.}},
author = {{Smith, Ruben and Lotharius, Julie and Brundin, Patrik}},
issn = {{0023-7205}},
language = {{swe}},
number = {{15}},
pages = {{6--1329}},
publisher = {{Swedish Medical Association}},
series = {{Läkartidningen}},
title = {{Fria radikaler och sjuka proteiner - bovarna bakom Parkinsons sjukdom?[Free radicals and ailing proteins - the culprits behind Parkinson’s disease?]}},
url = {{http://ltarkiv.lakartidningen.se/artNo26514}},
volume = {{100}},
year = {{2003}},
}