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Do Cyclodextrins Aggregate in Water? Insights from NMR Experiments

Valente, Artur J. M.; Carvalho, Rui A. and Söderman, Olle LU (2015) In Langmuir 31(23). p.6314-6320
Abstract
One decade ago Bonini et al. [Langmuir 2006, 22, 1478-1484] reported the occurrence of aggregates of beta-cyclodextrin in aqueous Solutions with sizes in the range from 90 nm to a few micrometers. The experimental technique used was cryo-TEM. This work followed a number of previous studies involving other physical parameters, such as viscosities and activity coefficients, the results of which were interpreted in terms of self-aggregation of cydodextrins. Since then, the ability of cyclodextrins to self-assemble were often used to explain and rationalize the supramolecular mechanisms involving cydodextrins. Here, the question of aggregation of native cyclodextrins (alpha-, beta-, and gamma-) in aqueous solutions is addressed by using H-1... (More)
One decade ago Bonini et al. [Langmuir 2006, 22, 1478-1484] reported the occurrence of aggregates of beta-cyclodextrin in aqueous Solutions with sizes in the range from 90 nm to a few micrometers. The experimental technique used was cryo-TEM. This work followed a number of previous studies involving other physical parameters, such as viscosities and activity coefficients, the results of which were interpreted in terms of self-aggregation of cydodextrins. Since then, the ability of cyclodextrins to self-assemble were often used to explain and rationalize the supramolecular mechanisms involving cydodextrins. Here, the question of aggregation of native cyclodextrins (alpha-, beta-, and gamma-) in aqueous solutions is addressed by using H-1 NMR techniques, including NMR diffusometry, relaxometry, and proton peak intensities. Within the detection limit of the NMR experiments, no aggregates of cyclodextrin were observed. If aggregates are present, the fraction of cyclodextrin in aggregates is quite small less than 1%. However, we cannot exclude the presence of transient clusters involving several cyclodextrin molecules where the lifetime Of the cluster is short. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
31
issue
23
pages
6314 - 6320
publisher
The American Chemical Society
external identifiers
  • wos:000356755300007
  • scopus:84934951670
ISSN
0743-7463
DOI
10.1021/acs.langmuir.5b01493
language
English
LU publication?
yes
id
07415eea-89d0-452f-975a-9979f7fa9394 (old id 7593511)
date added to LUP
2015-07-23 08:39:56
date last changed
2017-09-03 03:30:46
@article{07415eea-89d0-452f-975a-9979f7fa9394,
  abstract     = {One decade ago Bonini et al. [Langmuir 2006, 22, 1478-1484] reported the occurrence of aggregates of beta-cyclodextrin in aqueous Solutions with sizes in the range from 90 nm to a few micrometers. The experimental technique used was cryo-TEM. This work followed a number of previous studies involving other physical parameters, such as viscosities and activity coefficients, the results of which were interpreted in terms of self-aggregation of cydodextrins. Since then, the ability of cyclodextrins to self-assemble were often used to explain and rationalize the supramolecular mechanisms involving cydodextrins. Here, the question of aggregation of native cyclodextrins (alpha-, beta-, and gamma-) in aqueous solutions is addressed by using H-1 NMR techniques, including NMR diffusometry, relaxometry, and proton peak intensities. Within the detection limit of the NMR experiments, no aggregates of cyclodextrin were observed. If aggregates are present, the fraction of cyclodextrin in aggregates is quite small less than 1%. However, we cannot exclude the presence of transient clusters involving several cyclodextrin molecules where the lifetime Of the cluster is short.},
  author       = {Valente, Artur J. M. and Carvalho, Rui A. and Söderman, Olle},
  issn         = {0743-7463},
  language     = {eng},
  number       = {23},
  pages        = {6314--6320},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {Do Cyclodextrins Aggregate in Water? Insights from NMR Experiments},
  url          = {http://dx.doi.org/10.1021/acs.langmuir.5b01493},
  volume       = {31},
  year         = {2015},
}