Flow sensing in the cardiovascular system
(2015) In Colloids and Surfaces A: Physicochemical and Engineering Aspects 480. p.318-327- Abstract
- Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte heparan sulfate proteoglycan (HS-PG) reacts to the shear stress generated by the flowing blood. In the present investigation, this naturally occurring biosensor is characterized in more detail, which is crucially involved in the regulation of peripheral blood flow and organ perfusion. A dysfunction of this sensor can lead to organ insufficiency,... (More)
- Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte heparan sulfate proteoglycan (HS-PG) reacts to the shear stress generated by the flowing blood. In the present investigation, this naturally occurring biosensor is characterized in more detail, which is crucially involved in the regulation of peripheral blood flow and organ perfusion. A dysfunction of this sensor can lead to organ insufficiency, hypertension and arteriosclerosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7596529
- author
- Siegel, G. ; Meyer-Rath, G. ; Ermilov, E. ; Rodriguez, M. ; Malmsten, M. ; Claesson, P. ; Saunders, R. ; Hetzer, R. and Lindman, Björn LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Endothelial flow sensor syndecan (HS/CS-PG)
- in
- Colloids and Surfaces A: Physicochemical and Engineering Aspects
- volume
- 480
- pages
- 318 - 327
- publisher
- Elsevier
- external identifiers
-
- wos:000356051200040
- scopus:84937894891
- ISSN
- 0927-7757
- DOI
- 10.1016/j.colsurfa.2014.10.025
- language
- English
- LU publication?
- yes
- id
- b3b24f89-5bec-443a-8f6e-9f738ce2850d (old id 7596529)
- date added to LUP
- 2016-04-01 13:28:47
- date last changed
- 2022-01-27 19:25:23
@article{b3b24f89-5bec-443a-8f6e-9f738ce2850d,
abstract = {{Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte heparan sulfate proteoglycan (HS-PG) reacts to the shear stress generated by the flowing blood. In the present investigation, this naturally occurring biosensor is characterized in more detail, which is crucially involved in the regulation of peripheral blood flow and organ perfusion. A dysfunction of this sensor can lead to organ insufficiency, hypertension and arteriosclerosis.}},
author = {{Siegel, G. and Meyer-Rath, G. and Ermilov, E. and Rodriguez, M. and Malmsten, M. and Claesson, P. and Saunders, R. and Hetzer, R. and Lindman, Björn}},
issn = {{0927-7757}},
keywords = {{Endothelial flow sensor syndecan (HS/CS-PG)}},
language = {{eng}},
pages = {{318--327}},
publisher = {{Elsevier}},
series = {{Colloids and Surfaces A: Physicochemical and Engineering Aspects}},
title = {{Flow sensing in the cardiovascular system}},
url = {{http://dx.doi.org/10.1016/j.colsurfa.2014.10.025}},
doi = {{10.1016/j.colsurfa.2014.10.025}},
volume = {{480}},
year = {{2015}},
}