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Flow sensing in the cardiovascular system

Siegel, G.; Meyer-Rath, G.; Ermilov, E.; Rodriguez, M.; Malmsten, M.; Claesson, P.; Saunders, R.; Hetzer, R. and Lindman, Björn LU (2015) In Colloids and Surfaces A: Physicochemical and Engineering Aspects 480. p.318-327
Abstract
Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte heparan sulfate proteoglycan (HS-PG) reacts to the shear stress generated by the flowing blood. In the present investigation, this naturally occurring biosensor is characterized in more detail, which is crucially involved in the regulation of peripheral blood flow and organ perfusion. A dysfunction of this sensor can lead to organ insufficiency,... (More)
Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte heparan sulfate proteoglycan (HS-PG) reacts to the shear stress generated by the flowing blood. In the present investigation, this naturally occurring biosensor is characterized in more detail, which is crucially involved in the regulation of peripheral blood flow and organ perfusion. A dysfunction of this sensor can lead to organ insufficiency, hypertension and arteriosclerosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endothelial flow sensor syndecan (HS/CS-PG)
in
Colloids and Surfaces A: Physicochemical and Engineering Aspects
volume
480
pages
318 - 327
publisher
Elsevier
external identifiers
  • wos:000356051200040
  • scopus:84937894891
ISSN
0927-7757
DOI
10.1016/j.colsurfa.2014.10.025
language
English
LU publication?
yes
id
b3b24f89-5bec-443a-8f6e-9f738ce2850d (old id 7596529)
date added to LUP
2015-07-23 10:53:54
date last changed
2017-01-15 03:49:41
@article{b3b24f89-5bec-443a-8f6e-9f738ce2850d,
  abstract     = {Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte heparan sulfate proteoglycan (HS-PG) reacts to the shear stress generated by the flowing blood. In the present investigation, this naturally occurring biosensor is characterized in more detail, which is crucially involved in the regulation of peripheral blood flow and organ perfusion. A dysfunction of this sensor can lead to organ insufficiency, hypertension and arteriosclerosis.},
  author       = {Siegel, G. and Meyer-Rath, G. and Ermilov, E. and Rodriguez, M. and Malmsten, M. and Claesson, P. and Saunders, R. and Hetzer, R. and Lindman, Björn},
  issn         = {0927-7757},
  keyword      = {Endothelial flow sensor syndecan (HS/CS-PG)},
  language     = {eng},
  pages        = {318--327},
  publisher    = {Elsevier},
  series       = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},
  title        = {Flow sensing in the cardiovascular system},
  url          = {http://dx.doi.org/10.1016/j.colsurfa.2014.10.025},
  volume       = {480},
  year         = {2015},
}