Male-biased recombination at chromosome ends in a songbird revealed by precisely mapping crossover positions
Zhang, Hongkai LU ; Lundberg, Max LU ; Ponnikas, Suvi LU ; Hasselquist, Dennis LU and Hansson, Bengt LU
(2024)
In G3: Genes, Genomes, Genetics
14(9).
- Abstract
Recombination plays a crucial role in evolution by generating novel haplotypes and disrupting linkage between genes, thereby enhancing the efficiency of selection. Here, we analyze the genomes of 12 great reed warblers (Acrocephalus arundinaceus) in a 3-generation pedigree to identify precise crossover positions along the chromosomes. We located more than 200 crossovers and found that these were highly concentrated toward the telomeric ends of the chromosomes. Apart from this major pattern in the recombination landscape, we found significantly higher frequencies of crossovers in genic compared with intergenic regions, and in exons compared with introns. Moreover, while the number of recombination events was similar between the sexes,... (More)
Recombination plays a crucial role in evolution by generating novel haplotypes and disrupting linkage between genes, thereby enhancing the efficiency of selection. Here, we analyze the genomes of 12 great reed warblers (Acrocephalus arundinaceus) in a 3-generation pedigree to identify precise crossover positions along the chromosomes. We located more than 200 crossovers and found that these were highly concentrated toward the telomeric ends of the chromosomes. Apart from this major pattern in the recombination landscape, we found significantly higher frequencies of crossovers in genic compared with intergenic regions, and in exons compared with introns. Moreover, while the number of recombination events was similar between the sexes, the crossovers were located significantly closer to the ends of paternal compared with maternal chromosomes. In conclusion, our study of the great reed warbler revealed substantial variation in crossover frequencies within chromosomes, with a distinct bias toward the sub-telomeric regions, particularly on the paternal side. These findings emphasize the importance of thoroughly screening the entire length of chromosomes to characterize the recombination landscape and uncover potential sex-biases in recombination.
(Less)
- author
- Zhang, Hongkai
LU
; Lundberg, Max
LU
; Ponnikas, Suvi
LU
; Hasselquist, Dennis
LU
and Hansson, Bengt
LU
- organization
- publishing date
- 2024-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- crossover, great reed warbler, male bias, recombination, SNP, songbird, sub-telomeric regions
- in
- G3: Genes, Genomes, Genetics
- volume
- 14
- issue
- 9
- article number
- jkae150
- publisher
- Genetics Society of America
- external identifiers
-
- pmid:38985659
- scopus:85203418902
- ISSN
- 2160-1836
- DOI
- 10.1093/g3journal/jkae150
- language
- English
- LU publication?
- yes
- id
- 75b50ee7-bf19-40c1-a24a-2ade9c301345
- date added to LUP
- 2024-11-19 11:30:35
- date last changed
- 2025-07-02 06:39:56
@article{75b50ee7-bf19-40c1-a24a-2ade9c301345,
abstract = {{<p>Recombination plays a crucial role in evolution by generating novel haplotypes and disrupting linkage between genes, thereby enhancing the efficiency of selection. Here, we analyze the genomes of 12 great reed warblers (Acrocephalus arundinaceus) in a 3-generation pedigree to identify precise crossover positions along the chromosomes. We located more than 200 crossovers and found that these were highly concentrated toward the telomeric ends of the chromosomes. Apart from this major pattern in the recombination landscape, we found significantly higher frequencies of crossovers in genic compared with intergenic regions, and in exons compared with introns. Moreover, while the number of recombination events was similar between the sexes, the crossovers were located significantly closer to the ends of paternal compared with maternal chromosomes. In conclusion, our study of the great reed warbler revealed substantial variation in crossover frequencies within chromosomes, with a distinct bias toward the sub-telomeric regions, particularly on the paternal side. These findings emphasize the importance of thoroughly screening the entire length of chromosomes to characterize the recombination landscape and uncover potential sex-biases in recombination.</p>}},
author = {{Zhang, Hongkai and Lundberg, Max and Ponnikas, Suvi and Hasselquist, Dennis and Hansson, Bengt}},
issn = {{2160-1836}},
keywords = {{crossover; great reed warbler; male bias; recombination; SNP; songbird; sub-telomeric regions}},
language = {{eng}},
number = {{9}},
publisher = {{Genetics Society of America}},
series = {{G3: Genes, Genomes, Genetics}},
title = {{Male-biased recombination at chromosome ends in a songbird revealed by precisely mapping crossover positions}},
url = {{http://dx.doi.org/10.1093/g3journal/jkae150}},
doi = {{10.1093/g3journal/jkae150}},
volume = {{14}},
year = {{2024}},
}