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Tobacco smoking and alcohol consumption as risk factors for thymoma – A European case-control study

Eriksson, Mikael LU ; Kaerlev, Linda; Johansen, Preben; Afonso, Noemia; Ahrens, Wolfgang; Costa-Pereira, Altamiro; Guénel, Pascal; Jöckel, Karl Heinz; Gonzalez, Agustin Llopis and Merletti, Franco, et al. (2019) In Cancer Epidemiology 61. p.133-138
Abstract

Purpose: Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. Methods: A European multi-centre case-control study including incident cases aged 35–69 years with thymoma between 1995 and 1997, was conducted in seven countries. A set of controls, used in seven parallel case-control studies by the same research group was used, including population-based controls from five countries and hospital controls with colon cancer from two countries. Altogether 103 cases, accepted by a reference pathologist, 712 colon cancer controls, and 2071 population controls were interviewed.... (More)

Purpose: Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. Methods: A European multi-centre case-control study including incident cases aged 35–69 years with thymoma between 1995 and 1997, was conducted in seven countries. A set of controls, used in seven parallel case-control studies by the same research group was used, including population-based controls from five countries and hospital controls with colon cancer from two countries. Altogether 103 cases, accepted by a reference pathologist, 712 colon cancer controls, and 2071 population controls were interviewed. Results: Tobacco smoking was moderately related with thymoma (OR 1.4, 95% CI 0.9–2.2), and a tendency to dose-response was shown (p = 0.04), with an increased risk for heavy smokers defined as ≥41 pack-years (OR 2.1, 95% CI 1.1–3.9). A high consumption of spirits defined as ≥25 g of alcohol per day was associated with an increased risk of thymoma (OR 2.4, 95% CI 1.1–5.4), whereas no association was found with beer or wine. Conclusions: Tobacco smoking and a high intake of spirits were indicated as risk factors for thymoma.

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publication status
published
subject
keywords
Alcohol, Case-control study, Risk factors, Thymoma, Thymus cancer, Tobacco smoking
in
Cancer Epidemiology
volume
61
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85067898554
ISSN
1877-7821
DOI
10.1016/j.canep.2019.06.008
language
English
LU publication?
yes
id
75bc0a76-db94-4627-9857-9ff65a24b0e8
date added to LUP
2019-07-04 13:45:47
date last changed
2019-07-30 05:06:02
@article{75bc0a76-db94-4627-9857-9ff65a24b0e8,
  abstract     = {<p>Purpose: Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. Methods: A European multi-centre case-control study including incident cases aged 35–69 years with thymoma between 1995 and 1997, was conducted in seven countries. A set of controls, used in seven parallel case-control studies by the same research group was used, including population-based controls from five countries and hospital controls with colon cancer from two countries. Altogether 103 cases, accepted by a reference pathologist, 712 colon cancer controls, and 2071 population controls were interviewed. Results: Tobacco smoking was moderately related with thymoma (OR 1.4, 95% CI 0.9–2.2), and a tendency to dose-response was shown (p = 0.04), with an increased risk for heavy smokers defined as ≥41 pack-years (OR 2.1, 95% CI 1.1–3.9). A high consumption of spirits defined as ≥25 g of alcohol per day was associated with an increased risk of thymoma (OR 2.4, 95% CI 1.1–5.4), whereas no association was found with beer or wine. Conclusions: Tobacco smoking and a high intake of spirits were indicated as risk factors for thymoma.</p>},
  author       = {Eriksson, Mikael and Kaerlev, Linda and Johansen, Preben and Afonso, Noemia and Ahrens, Wolfgang and Costa-Pereira, Altamiro and Guénel, Pascal and Jöckel, Karl Heinz and Gonzalez, Agustin Llopis and Merletti, Franco and Suárez-Varela, Maria Morales and Trétarre, Brigitte and Wingren, Gun and Richiardi, Lorenzo and Sabroe, Svend},
  issn         = {1877-7821},
  keyword      = {Alcohol,Case-control study,Risk factors,Thymoma,Thymus cancer,Tobacco smoking},
  language     = {eng},
  pages        = {133--138},
  publisher    = {Elsevier},
  series       = {Cancer Epidemiology},
  title        = {Tobacco smoking and alcohol consumption as risk factors for thymoma – A European case-control study},
  url          = {http://dx.doi.org/10.1016/j.canep.2019.06.008},
  volume       = {61},
  year         = {2019},
}