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Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI)

Zeeuw van der Laan, Eveline A.N. ; van der Velden, Saskia ; Porcelijn, Leendert ; Semple, John W. LU ; van der Schoot, C. Ellen and Kapur, Rick LU (2020) In Transfusion Medicine Reviews 34(4). p.227-233
Abstract

Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions, especially under inflammatory conditions. Depending on the specific setting, platelets may be either protective or pathogenic in acute lung injury and acute respiratory distress syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well defined; however, it has been hypothesized that recipient platelets and transfused platelets both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that recipient platelets may play a pathogenic role in antibody-mediated TRALI; however, their contribution appears to be limited. It is imperative to first validate the involvement of recipient platelets... (More)

Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions, especially under inflammatory conditions. Depending on the specific setting, platelets may be either protective or pathogenic in acute lung injury and acute respiratory distress syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well defined; however, it has been hypothesized that recipient platelets and transfused platelets both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that recipient platelets may play a pathogenic role in antibody-mediated TRALI; however, their contribution appears to be limited. It is imperative to first validate the involvement of recipient platelets by standardizing the animal models, methods, reagents, and readouts for lung injury and taking the animal housing environment into consideration. For the involvement of transfused platelets in TRALI, it appears that predominantly lipids such as ceramide in stored platelets are able to induce TRALI in animal models. These studies will also need to be validated, and moreover, the platelet-derived lipid-mediated mechanisms leading to TRALI will need to be investigated.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
34-1-2S, Ceramide, Lipids, Platelets, TRALI, Transfusion-related acute lung injury
in
Transfusion Medicine Reviews
volume
34
issue
4
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:33036839
  • scopus:85092082381
ISSN
0887-7963
DOI
10.1016/j.tmrv.2020.08.002
language
English
LU publication?
yes
id
75c6c31d-c232-432f-bcc2-033e4d009824
date added to LUP
2020-11-03 11:40:27
date last changed
2024-06-28 03:03:53
@article{75c6c31d-c232-432f-bcc2-033e4d009824,
  abstract     = {{<p>Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions, especially under inflammatory conditions. Depending on the specific setting, platelets may be either protective or pathogenic in acute lung injury and acute respiratory distress syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well defined; however, it has been hypothesized that recipient platelets and transfused platelets both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that recipient platelets may play a pathogenic role in antibody-mediated TRALI; however, their contribution appears to be limited. It is imperative to first validate the involvement of recipient platelets by standardizing the animal models, methods, reagents, and readouts for lung injury and taking the animal housing environment into consideration. For the involvement of transfused platelets in TRALI, it appears that predominantly lipids such as ceramide in stored platelets are able to induce TRALI in animal models. These studies will also need to be validated, and moreover, the platelet-derived lipid-mediated mechanisms leading to TRALI will need to be investigated.</p>}},
  author       = {{Zeeuw van der Laan, Eveline A.N. and van der Velden, Saskia and Porcelijn, Leendert and Semple, John W. and van der Schoot, C. Ellen and Kapur, Rick}},
  issn         = {{0887-7963}},
  keywords     = {{34-1-2S; Ceramide; Lipids; Platelets; TRALI; Transfusion-related acute lung injury}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{227--233}},
  publisher    = {{Elsevier}},
  series       = {{Transfusion Medicine Reviews}},
  title        = {{Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI)}},
  url          = {{http://dx.doi.org/10.1016/j.tmrv.2020.08.002}},
  doi          = {{10.1016/j.tmrv.2020.08.002}},
  volume       = {{34}},
  year         = {{2020}},
}