Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Ventricular-arterial coupling as a potential therapeutic target in diabetes

Saeed, Sahrai ; Holm, Hannes LU and Nilsson, Peter LU (2021) In Journal of the Pakistan Medical Association 71(11). p.2637-2640
Abstract

Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and heart failure reduce cardiovascular risk and heart failure-related hospitalisations. SGLT-2i treatment has been shown to improve the long-term prognosis of patients with heart failure. Both drugs also have the potential to normalise ventricular-arterial coupling (VAC). VAC is the crosstalk between the left ventricular function and arterial system,... (More)

Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and heart failure reduce cardiovascular risk and heart failure-related hospitalisations. SGLT-2i treatment has been shown to improve the long-term prognosis of patients with heart failure. Both drugs also have the potential to normalise ventricular-arterial coupling (VAC). VAC is the crosstalk between the left ventricular function and arterial system, and is an indicator of the global cardiovascular performance. In this overview, we will describe the concept of VAC and the features of diabetic cardiomyopathy, as well as VAC as a potential therapeutic target in diabetes by the use of novel anti-diabetic drugs, primarily SGLT-2i and GLP-1RA.

(Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes, Glucagon-like peptide-1 receptor agonists, Sodium-glucose cotransporter-2 inhibitors, Ventricular-arterial coupling
in
Journal of the Pakistan Medical Association
volume
71
issue
11
pages
4 pages
publisher
Pakistan Medical Association
external identifiers
  • scopus:85119035660
  • pmid:34783749
ISSN
0030-9982
DOI
10.47391/JPMA.01279
language
English
LU publication?
yes
id
75c9ee06-4685-45f3-9fdc-fc28981fd1d5
date added to LUP
2022-01-04 10:57:53
date last changed
2024-03-23 16:52:31
@article{75c9ee06-4685-45f3-9fdc-fc28981fd1d5,
  abstract     = {{<p>Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and heart failure reduce cardiovascular risk and heart failure-related hospitalisations. SGLT-2i treatment has been shown to improve the long-term prognosis of patients with heart failure. Both drugs also have the potential to normalise ventricular-arterial coupling (VAC). VAC is the crosstalk between the left ventricular function and arterial system, and is an indicator of the global cardiovascular performance. In this overview, we will describe the concept of VAC and the features of diabetic cardiomyopathy, as well as VAC as a potential therapeutic target in diabetes by the use of novel anti-diabetic drugs, primarily SGLT-2i and GLP-1RA.</p>}},
  author       = {{Saeed, Sahrai and Holm, Hannes and Nilsson, Peter}},
  issn         = {{0030-9982}},
  keywords     = {{Diabetes; Glucagon-like peptide-1 receptor agonists; Sodium-glucose cotransporter-2 inhibitors; Ventricular-arterial coupling}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2637--2640}},
  publisher    = {{Pakistan Medical Association}},
  series       = {{Journal of the Pakistan Medical Association}},
  title        = {{Ventricular-arterial coupling as a potential therapeutic target in diabetes}},
  url          = {{http://dx.doi.org/10.47391/JPMA.01279}},
  doi          = {{10.47391/JPMA.01279}},
  volume       = {{71}},
  year         = {{2021}},
}