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The specific organism : Not bacterial gram type: Drives the inflammatory response in septic shock

Linder, Adam LU ; Fjell, Chris D. ; Inghammar, Malin LU ; Hsu, Joseph ; Walley, Keith R. ; Boyd, John H. and Russell, James A. (2020) In Journal of Innate Immunity 12(2). p.182-190
Abstract

Background and Hypothesis: The inflammatory response was targeted by unsuccessful therapies but ignored pathogen. We hypothesized that the inflammatory response differs according to organism in human septic shock. Materials and Methods: We measured 39 cytokines at baseline and 24 h in patients (n = 363) in the Vasopressin and Septic Shock Trial (VASST). We compared cytokine profiles (cytokine functional class) at baseline and at 24 h by organism and used hierarchical clustering to classify cytokines according to 28-day outcomes. Results: In 363 patients, 88 and 176 patients had at least 1 species isolated from blood and other sites, respectively. Cytokine levels differed significantly according to organism: Neisseria meningitidis and... (More)

Background and Hypothesis: The inflammatory response was targeted by unsuccessful therapies but ignored pathogen. We hypothesized that the inflammatory response differs according to organism in human septic shock. Materials and Methods: We measured 39 cytokines at baseline and 24 h in patients (n = 363) in the Vasopressin and Septic Shock Trial (VASST). We compared cytokine profiles (cytokine functional class) at baseline and at 24 h by organism and used hierarchical clustering to classify cytokines according to 28-day outcomes. Results: In 363 patients, 88 and 176 patients had at least 1 species isolated from blood and other sites, respectively. Cytokine levels differed significantly according to organism: Neisseria meningitidis and Streptococcus pneumoniae had the highest (baseline and at 24 h), while Enterococcus faecalis (blood) had the lowest mean cytokine levels. N. meningitidis and Klebsiella pneumoniae had significantly higher cytokine levels at baseline versus 24 h (p = 0.01 and 0.02, respectively); E. faecalis had significantly higher cytokine levels at 24 h versus baseline. Hierarchical clustering heat maps showed that pathogens elicited similar cytokine responses not related to the functional cytokine class. Conclusion: The organism type induces different cytokine profiles in septic shock. Specific gram-positive and gram-negative pathogens stimulated similar plasma cytokine-level patterns.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cytokines, Gram type, Inflammation, Organism, Pathogen, Septic shock
in
Journal of Innate Immunity
volume
12
issue
2
pages
9 pages
publisher
Karger
external identifiers
  • scopus:85068620585
  • pmid:31242491
ISSN
1662-811X
DOI
10.1159/000500418
language
English
LU publication?
yes
id
75f2045e-a9fe-4cbc-a95f-cd6a1ec6b198
date added to LUP
2019-07-19 09:38:44
date last changed
2025-04-04 15:26:57
@article{75f2045e-a9fe-4cbc-a95f-cd6a1ec6b198,
  abstract     = {{<p>Background and Hypothesis: The inflammatory response was targeted by unsuccessful therapies but ignored pathogen. We hypothesized that the inflammatory response differs according to organism in human septic shock. Materials and Methods: We measured 39 cytokines at baseline and 24 h in patients (n = 363) in the Vasopressin and Septic Shock Trial (VASST). We compared cytokine profiles (cytokine functional class) at baseline and at 24 h by organism and used hierarchical clustering to classify cytokines according to 28-day outcomes. Results: In 363 patients, 88 and 176 patients had at least 1 species isolated from blood and other sites, respectively. Cytokine levels differed significantly according to organism: Neisseria meningitidis and Streptococcus pneumoniae had the highest (baseline and at 24 h), while Enterococcus faecalis (blood) had the lowest mean cytokine levels. N. meningitidis and Klebsiella pneumoniae had significantly higher cytokine levels at baseline versus 24 h (p = 0.01 and 0.02, respectively); E. faecalis had significantly higher cytokine levels at 24 h versus baseline. Hierarchical clustering heat maps showed that pathogens elicited similar cytokine responses not related to the functional cytokine class. Conclusion: The organism type induces different cytokine profiles in septic shock. Specific gram-positive and gram-negative pathogens stimulated similar plasma cytokine-level patterns.</p>}},
  author       = {{Linder, Adam and Fjell, Chris D. and Inghammar, Malin and Hsu, Joseph and Walley, Keith R. and Boyd, John H. and Russell, James A.}},
  issn         = {{1662-811X}},
  keywords     = {{Cytokines; Gram type; Inflammation; Organism; Pathogen; Septic shock}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{182--190}},
  publisher    = {{Karger}},
  series       = {{Journal of Innate Immunity}},
  title        = {{The specific organism : Not bacterial gram type: Drives the inflammatory response in septic shock}},
  url          = {{http://dx.doi.org/10.1159/000500418}},
  doi          = {{10.1159/000500418}},
  volume       = {{12}},
  year         = {{2020}},
}