Accumulation of advanced glycation end products in skin and increased vascular ageing in the general population : The Malmö Offspring Study
Jujic, Amra LU ; Engström, Gunnar LU ; Nilsson, Peter M LU and Johansson, Madeleine LU
(2023)
In Journal of Hypertension
p.1-8
- Abstract
OBJECTIVES: Advanced glycation end product (AGE) is an established risk marker for diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in middle-aged and older individuals. The relationship between AGEs and aortic stiffness has not been thoroughly examined in the younger general population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and middle-aged adults.
METHODS: We analysed cross-sectionally 2518 participants from a Swedish population-based cohort, the Malmö Offspring Study (mean age 41.8 ± 14.5 years, 52.2%). Advanced glycation end-products (AGEs) were measured by a well validated, noninvasive... (More)
OBJECTIVES: Advanced glycation end product (AGE) is an established risk marker for diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in middle-aged and older individuals. The relationship between AGEs and aortic stiffness has not been thoroughly examined in the younger general population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and middle-aged adults.
METHODS: We analysed cross-sectionally 2518 participants from a Swedish population-based cohort, the Malmö Offspring Study (mean age 41.8 ± 14.5 years, 52.2%). Advanced glycation end-products (AGEs) were measured by a well validated, noninvasive method using skin autofluorescence with AGE-Reader. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (PWV) and augmentation index (Aix) was calibrated to a standard heart rate of 75 bpm at the arteria radialis using SphygmoCor. Multivariable linear regression was performed stratified by age to analyse the association between skin AGE and aortic stiffness.
RESULTS: Increased levels of AGEs were significantly associated with higher direct measurements of aortic stiffness (vascular ageing) in younger individuals (PWV β 0.55 m/s, P < 0.001) after adjustment for traditional cardiometabolic risk factors, however, not in older individuals (PWV β 0.23 m/s, P = 0.10). Indirect vascular ageing was also significantly associated with higher levels of AGEs in both younger (Aix β 7.78, P < 0.001) and older individuals (Aix β 3.69, P < 0.001).
CONCLUSION: Higher levels of skin autofluorescence-AGEs are positively associated with increased vascular ageing in younger adults from the general population, independent of cardiometabolic risk factors.
(Less)
- author
- Jujic, Amra
LU
; Engström, Gunnar
LU
; Nilsson, Peter M
LU
and Johansson, Madeleine
LU
- organization
- publishing date
- 2023-12-05
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- aortic stiffness, vascular ageing, advanced glycation end products
- in
- Journal of Hypertension
- pages
- 1 - 8
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85183959357
- pmid:38088420
- ISSN
- 1473-5598
- DOI
- 10.1097/HJH.0000000000003627
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
- id
- 763894e2-cf2e-45cc-a937-bb6eebecec5e
- date added to LUP
- 2023-12-14 15:27:48
- date last changed
- 2024-04-25 22:37:12
@article{763894e2-cf2e-45cc-a937-bb6eebecec5e,
abstract = {{<p>OBJECTIVES: Advanced glycation end product (AGE) is an established risk marker for diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in middle-aged and older individuals. The relationship between AGEs and aortic stiffness has not been thoroughly examined in the younger general population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and middle-aged adults.</p><p>METHODS: We analysed cross-sectionally 2518 participants from a Swedish population-based cohort, the Malmö Offspring Study (mean age 41.8 ± 14.5 years, 52.2%). Advanced glycation end-products (AGEs) were measured by a well validated, noninvasive method using skin autofluorescence with AGE-Reader. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (PWV) and augmentation index (Aix) was calibrated to a standard heart rate of 75 bpm at the arteria radialis using SphygmoCor. Multivariable linear regression was performed stratified by age to analyse the association between skin AGE and aortic stiffness.</p><p>RESULTS: Increased levels of AGEs were significantly associated with higher direct measurements of aortic stiffness (vascular ageing) in younger individuals (PWV β 0.55 m/s, P < 0.001) after adjustment for traditional cardiometabolic risk factors, however, not in older individuals (PWV β 0.23 m/s, P = 0.10). Indirect vascular ageing was also significantly associated with higher levels of AGEs in both younger (Aix β 7.78, P < 0.001) and older individuals (Aix β 3.69, P < 0.001).</p><p>CONCLUSION: Higher levels of skin autofluorescence-AGEs are positively associated with increased vascular ageing in younger adults from the general population, independent of cardiometabolic risk factors.</p>}},
author = {{Jujic, Amra and Engström, Gunnar and Nilsson, Peter M and Johansson, Madeleine}},
issn = {{1473-5598}},
keywords = {{aortic stiffness; vascular ageing; advanced glycation end products}},
language = {{eng}},
month = {{12}},
pages = {{1--8}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Accumulation of advanced glycation end products in skin and increased vascular ageing in the general population : The Malmö Offspring Study}},
url = {{http://dx.doi.org/10.1097/HJH.0000000000003627}},
doi = {{10.1097/HJH.0000000000003627}},
year = {{2023}},
}