Bubble coalescence in breathing DNA: Two vicious walkers in opposite potentials
(2007) In Europhysics Letters 77(4).- Abstract
- We investigate the coalescence of two DNA bubbles initially located at weak segments and separated by a more stable barrier region in a designed construct of double-stranded DNA. The characteristic time for bubble coalescence and the corresponding distribution are derived, as well as the distribution of coalescence positions along the barrier. Below the melting temperature, we find a Kramers-type barrier crossing behaviour, while at high temperatures, the bubble corners perform drift-diffusion towards coalescence. The results are obtained by mapping the bubble dynamics on the problem of two vicious walkers in opposite potentials.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/764158
- author
- Novotny, T. ; Pedersen, Jonas LU ; Ambjörnsson, T. LU ; Hansen, M. S. and Metzler, R.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Europhysics Letters
- volume
- 77
- issue
- 4
- article number
- 48001
- publisher
- EDP Sciences
- external identifiers
-
- wos:000245743300025
- scopus:78951496074
- ISSN
- 0295-5075
- DOI
- 10.1209/0295-5075/77/48001
- language
- English
- LU publication?
- yes
- id
- 3e1b6c06-f5fb-4faf-9b74-00cfe054cc76 (old id 764158)
- date added to LUP
- 2016-04-01 12:34:52
- date last changed
- 2022-03-31 17:18:07
@article{3e1b6c06-f5fb-4faf-9b74-00cfe054cc76, abstract = {{We investigate the coalescence of two DNA bubbles initially located at weak segments and separated by a more stable barrier region in a designed construct of double-stranded DNA. The characteristic time for bubble coalescence and the corresponding distribution are derived, as well as the distribution of coalescence positions along the barrier. Below the melting temperature, we find a Kramers-type barrier crossing behaviour, while at high temperatures, the bubble corners perform drift-diffusion towards coalescence. The results are obtained by mapping the bubble dynamics on the problem of two vicious walkers in opposite potentials.}}, author = {{Novotny, T. and Pedersen, Jonas and Ambjörnsson, T. and Hansen, M. S. and Metzler, R.}}, issn = {{0295-5075}}, language = {{eng}}, number = {{4}}, publisher = {{EDP Sciences}}, series = {{Europhysics Letters}}, title = {{Bubble coalescence in breathing DNA: Two vicious walkers in opposite potentials}}, url = {{http://dx.doi.org/10.1209/0295-5075/77/48001}}, doi = {{10.1209/0295-5075/77/48001}}, volume = {{77}}, year = {{2007}}, }