Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat
Baekkeskov, Steinunn ; Dyrberg, Thomas and Lernmark, Å K.E. LU
(1984)
In Science
224(4655).
p.1348-1350
- Abstract
Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/76767b68-da16-4ccd-904c-f228bce6f164
- author
- Baekkeskov, Steinunn
; Dyrberg, Thomas
and Lernmark, Å K.E.
LU
- publishing date
- 1984-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Science
- volume
- 224
- issue
- 4655
- pages
- 3 pages
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:6374896
- scopus:0021237044
- ISSN
- 0036-8075
- DOI
- 10.1126/science.6374896
- language
- English
- LU publication?
- no
- id
- 76767b68-da16-4ccd-904c-f228bce6f164
- date added to LUP
- 2019-09-16 12:43:07
- date last changed
- 2024-03-13 08:15:15
@article{76767b68-da16-4ccd-904c-f228bce6f164,
abstract = {{<p>Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.</p>}},
author = {{Baekkeskov, Steinunn and Dyrberg, Thomas and Lernmark, Å K.E.}},
issn = {{0036-8075}},
language = {{eng}},
month = {{01}},
number = {{4655}},
pages = {{1348--1350}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science}},
title = {{Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat}},
url = {{http://dx.doi.org/10.1126/science.6374896}},
doi = {{10.1126/science.6374896}},
volume = {{224}},
year = {{1984}},
}