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Even at 100+ : Acute Exercise Modulates Inflammatory Pathways in Centenarians

Plaza-Florido, Abel ; Alejo, Lidia B. ; Pérez-Prieto, Inmaculada ; Carrera-Bastos, Pedro LU ; Muñoz, María Rosado ; Aldazabal, Itziar Pagola ; Barranco-Gil, David ; Santos-Lozano, Alejandro ; Rodríguez-Romo, Gabriel and Yanguas-Casás, Natalia , et al. (2025) In Aging Cell 24(9).
Abstract

Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100–104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Aging Cell
volume
24
issue
9
article number
e70152
publisher
Wiley-Blackwell
external identifiers
  • scopus:105010430355
  • pmid:40874701
ISSN
1474-9718
DOI
10.1111/acel.70152
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
id
767e8b68-778c-4be0-8a07-9064af8189ca
date added to LUP
2026-01-29 14:31:07
date last changed
2026-01-30 03:00:01
@article{767e8b68-778c-4be0-8a07-9064af8189ca,
  abstract     = {{<p>Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100–104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.</p>}},
  author       = {{Plaza-Florido, Abel and Alejo, Lidia B. and Pérez-Prieto, Inmaculada and Carrera-Bastos, Pedro and Muñoz, María Rosado and Aldazabal, Itziar Pagola and Barranco-Gil, David and Santos-Lozano, Alejandro and Rodríguez-Romo, Gabriel and Yanguas-Casás, Natalia and Radom-Aizik, Shlomit and Lucia, Alejandro and Fiuza-Luces, Carmen}},
  issn         = {{1474-9718}},
  language     = {{eng}},
  number       = {{9}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Aging Cell}},
  title        = {{Even at 100+ : Acute Exercise Modulates Inflammatory Pathways in Centenarians}},
  url          = {{http://dx.doi.org/10.1111/acel.70152}},
  doi          = {{10.1111/acel.70152}},
  volume       = {{24}},
  year         = {{2025}},
}