An improved method for detecting and delineating genomic regions with altered gene expression in cancer
(2008) In Genome Biology 9(1).- Abstract
- ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1143863
- author
- Nilsson, Björn LU ; Johansson, Mikael ; Heyden, Anders LU ; Nelander, Sven and Fioretos, Thoas LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genome Biology
- volume
- 9
- issue
- 1
- article number
- R13
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:18208590
- wos:000253779800021
- scopus:46249086537
- pmid:18208590
- ISSN
- 1474-7596
- DOI
- 10.1186/gb-2008-9-1-r13
- language
- English
- LU publication?
- yes
- id
- 76b0d4ba-4057-424d-bcfb-8dae11c50cc0 (old id 1143863)
- date added to LUP
- 2016-04-01 13:09:25
- date last changed
- 2024-10-09 22:19:41
@article{76b0d4ba-4057-424d-bcfb-8dae11c50cc0, abstract = {{ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.}}, author = {{Nilsson, Björn and Johansson, Mikael and Heyden, Anders and Nelander, Sven and Fioretos, Thoas}}, issn = {{1474-7596}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Genome Biology}}, title = {{An improved method for detecting and delineating genomic regions with altered gene expression in cancer}}, url = {{http://dx.doi.org/10.1186/gb-2008-9-1-r13}}, doi = {{10.1186/gb-2008-9-1-r13}}, volume = {{9}}, year = {{2008}}, }