Computational multiscale modeling of embryo development.
(2012) In Current Opinion in Genetics & Development- Abstract
- Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3124135
- author
- Krupinski, Pawel LU ; Chickarmane, Vijay and Peterson, Carsten LU
- organization
- publishing date
- 2012-09-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Genetics & Development
- publisher
- Elsevier
- external identifiers
-
- wos:000314490300014
- pmid:22959149
- scopus:84872662899
- pmid:22959149
- ISSN
- 1879-0380
- DOI
- 10.1016/j.gde.2012.08.006
- language
- English
- LU publication?
- yes
- id
- 76cd779c-fb7b-4510-a6db-fd5156f547e9 (old id 3124135)
- date added to LUP
- 2016-04-01 14:05:09
- date last changed
- 2024-01-09 22:52:23
@article{76cd779c-fb7b-4510-a6db-fd5156f547e9, abstract = {{Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.}}, author = {{Krupinski, Pawel and Chickarmane, Vijay and Peterson, Carsten}}, issn = {{1879-0380}}, language = {{eng}}, month = {{09}}, publisher = {{Elsevier}}, series = {{Current Opinion in Genetics & Development}}, title = {{Computational multiscale modeling of embryo development.}}, url = {{http://dx.doi.org/10.1016/j.gde.2012.08.006}}, doi = {{10.1016/j.gde.2012.08.006}}, year = {{2012}}, }