Advanced

Sarcoidosis and Autoimmunity: Evidence of Differential Associations with HLA Class II Markers

Papadopoulos, K I ; Wassmuth, R ; Sponsel, T ; Sjöberg, K and Hallengren, Bengt LU (2006) In International Journal of Endocrinology and Metabolism 4(1). p.13-18
Abstract
A high frequency of endocrine autoimmunity

and gastrointestinal immune

reactivity has been reported in sarcoidosis.

The aim of the present study was

to determine the immunogenetic background of

sarcoidosis focusing on the associated autoimmune

manifestations.

Materials and Methods: A total of 66 (38 males,

28 females) and /65 (37 males, 28 females) Caucasian

patients with documented sarcoidosis diagnosed

at the Department of Pulmonary Medicine,

Malmö University Hospital were genomically

typed for DRB1/DQB1.

Results: The frequencies of HLA-DRB1*02

(p=0.004), DRB1*14 (p=0.022), DQB1*0602

(p=0.027), DQB1*0503... (More)
A high frequency of endocrine autoimmunity

and gastrointestinal immune

reactivity has been reported in sarcoidosis.

The aim of the present study was

to determine the immunogenetic background of

sarcoidosis focusing on the associated autoimmune

manifestations.

Materials and Methods: A total of 66 (38 males,

28 females) and /65 (37 males, 28 females) Caucasian

patients with documented sarcoidosis diagnosed

at the Department of Pulmonary Medicine,

Malmö University Hospital were genomically

typed for DRB1/DQB1.

Results: The frequencies of HLA-DRB1*02

(p=0.004), DRB1*14 (p=0.022), DQB1*0602

(p=0.027), DQB1*0503 (p=0.022), were significantly

increased in the whole group of patients

with sarcoidosis as well as in sarcoidosis associated

with autoimmune manifestations compared

to healthy controls.

Conclusions: Significant associations of HLADRB1*

02 and *14 and DQB1*0602 and *0503 with

sarcoidosis were found, particularly apparent in

the subgroup with associated autoimmune manifestations.

Different immunogenetic profiles

may thus exist in sarcoidosis indicative and/or

causative of distinct clinical subgroups. HLA

class II presentation of a putative sarcoidosisspecific

antigen might be of vital importance in

sarcoidosis, deciding the direction of the sarcoid

disease and eventual associations with it.

Whether the above mentioned HLA class II haplotypes

and/or their linked genes, alone or in

unison with HLA class I, are organ- or diseasespecific

remains to be determined. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Sarcoidosis, Thyroid, Polyglandular Autoimmune Syndromes, HLA, Autoimmunity
in
International Journal of Endocrinology and Metabolism
volume
4
issue
1
pages
13 - 18
publisher
Iran Endocrine Society, Shaheed Beheshti University of Medical Sciences
ISSN
1726-913X
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400)
id
76f81589-2e53-4624-a753-3bbad37cf510 (old id 1137005)
alternative location
http://www.ijem.org/PDF/Vol4No1.pdf
date added to LUP
2016-04-01 15:20:45
date last changed
2018-11-21 20:33:58
@article{76f81589-2e53-4624-a753-3bbad37cf510,
  abstract     = {A high frequency of endocrine autoimmunity<br/><br>
and gastrointestinal immune<br/><br>
reactivity has been reported in sarcoidosis.<br/><br>
The aim of the present study was<br/><br>
to determine the immunogenetic background of<br/><br>
sarcoidosis focusing on the associated autoimmune<br/><br>
manifestations.<br/><br>
Materials and Methods: A total of 66 (38 males,<br/><br>
28 females) and /65 (37 males, 28 females) Caucasian<br/><br>
patients with documented sarcoidosis diagnosed<br/><br>
at the Department of Pulmonary Medicine,<br/><br>
Malmö University Hospital were genomically<br/><br>
typed for DRB1/DQB1.<br/><br>
Results: The frequencies of HLA-DRB1*02<br/><br>
(p=0.004), DRB1*14 (p=0.022), DQB1*0602<br/><br>
(p=0.027), DQB1*0503 (p=0.022), were significantly<br/><br>
increased in the whole group of patients<br/><br>
with sarcoidosis as well as in sarcoidosis associated<br/><br>
with autoimmune manifestations compared<br/><br>
to healthy controls.<br/><br>
Conclusions: Significant associations of HLADRB1*<br/><br>
02 and *14 and DQB1*0602 and *0503 with<br/><br>
sarcoidosis were found, particularly apparent in<br/><br>
the subgroup with associated autoimmune manifestations.<br/><br>
Different immunogenetic profiles<br/><br>
may thus exist in sarcoidosis indicative and/or<br/><br>
causative of distinct clinical subgroups. HLA<br/><br>
class II presentation of a putative sarcoidosisspecific<br/><br>
antigen might be of vital importance in<br/><br>
sarcoidosis, deciding the direction of the sarcoid<br/><br>
disease and eventual associations with it.<br/><br>
Whether the above mentioned HLA class II haplotypes<br/><br>
and/or their linked genes, alone or in<br/><br>
unison with HLA class I, are organ- or diseasespecific<br/><br>
remains to be determined.},
  author       = {Papadopoulos, K I and Wassmuth, R and Sponsel, T and Sjöberg, K and Hallengren, Bengt},
  issn         = {1726-913X},
  language     = {eng},
  number       = {1},
  pages        = {13--18},
  publisher    = {Iran Endocrine Society, Shaheed Beheshti University of Medical Sciences},
  series       = {International Journal of Endocrinology and Metabolism},
  title        = {Sarcoidosis and Autoimmunity: Evidence of Differential Associations with HLA Class II Markers},
  url          = {http://www.ijem.org/PDF/Vol4No1.pdf},
  volume       = {4},
  year         = {2006},
}