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Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

Bastide, Matthieu F; Meissner, Wassilios G; Picconi, Barbara; Fasano, Stefania; Fernagut, Pierre-Olivier; Feyder, Michael; Francardo, Veronica LU ; Alcacer, Cristina LU ; Ding, Yunmin and Brambilla, Riccardo, et al. (2015) In Progress in Neurobiology 132(Jul 21). p.96-168
Abstract
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system... (More)
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms. (Less)
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published
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Progress in Neurobiology
volume
132
issue
Jul 21
pages
96 - 168
publisher
Elsevier
external identifiers
  • pmid:26209473
  • wos:000361404000005
  • scopus:84940452532
ISSN
1873-5118
DOI
10.1016/j.pneurobio.2015.07.002
language
English
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yes
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e5a6246e-f465-487d-972f-5547a1a3d1a7 (old id 7720896)
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http://www.ncbi.nlm.nih.gov/pubmed/26209473?dopt=Abstract
date added to LUP
2015-08-10 17:17:59
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2017-11-12 03:16:45
@article{e5a6246e-f465-487d-972f-5547a1a3d1a7,
  abstract     = {Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.},
  author       = {Bastide, Matthieu F and Meissner, Wassilios G and Picconi, Barbara and Fasano, Stefania and Fernagut, Pierre-Olivier and Feyder, Michael and Francardo, Veronica and Alcacer, Cristina and Ding, Yunmin and Brambilla, Riccardo and Fisone, Gilberto and Jon Stoessl, A and Bourdenx, Mathieu and Engeln, Michel and Navailles, Sylvia and De Deurwaerdère, Philippe and Ko, Wai Kin D and Simola, Nicola and Morelli, Micaela and Groc, Laurent and Rodriguez, Maria-Cruz and Gurevich, Eugenia V and Quik, Maryka and Morari, Michele and Mellone, Manuela and Gardoni, Fabrizio and Tronci, Elisabetta and Guehl, Dominique and Tison, François and Crossman, Alan R and Kang, Un Jung and Steece-Collier, Kathy and Fox, Susan and Carta, Manolo and Cenci Nilsson, Angela and Bézard, Erwan},
  issn         = {1873-5118},
  language     = {eng},
  number       = {Jul 21},
  pages        = {96--168},
  publisher    = {Elsevier},
  series       = {Progress in Neurobiology},
  title        = {Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.},
  url          = {http://dx.doi.org/10.1016/j.pneurobio.2015.07.002},
  volume       = {132},
  year         = {2015},
}