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Charged polymer membrane translocation

Ambjörnsson, T. LU ; Apell, S. P. ; Konkoli, Z. ; Di Marzio, E. A. and Kasianowicz, J. J. (2002) In The Journal of chemical physics 117(8). p.4063-4073
Abstract
We study the process of charged polymer translocation, driven by an external electric potential, through a narrow pore in a membrane. We assume that the number of polymer segments, m, having passed the entrance pore mouth, is a slow variable governing the translocation process. Outside the pore the probability that there is an end segment at the entrance pore mouth, is taken as the relevant parameter. In particular we derive an expression for the free energy as a function of m, F(m). F(m) is used in the Smoluchowski equation in order to obtain the flux of polymers through the pore. In the low voltage regime we find a thresholdlike behavior and exponential dependence on voltage. Above this regime the flux depends linearly on the applied... (More)
We study the process of charged polymer translocation, driven by an external electric potential, through a narrow pore in a membrane. We assume that the number of polymer segments, m, having passed the entrance pore mouth, is a slow variable governing the translocation process. Outside the pore the probability that there is an end segment at the entrance pore mouth, is taken as the relevant parameter. In particular we derive an expression for the free energy as a function of m, F(m). F(m) is used in the Smoluchowski equation in order to obtain the flux of polymers through the pore. In the low voltage regime we find a thresholdlike behavior and exponential dependence on voltage. Above this regime the flux depends linearly on the applied voltage. At very high voltages the process is diffusion limited and the flux saturates to a constant value. The model accounts for all features of the recent experiments by Henrickson et al. [Phys. Rev. Lett. 85, 3057 (2000)] for the flux of DNA molecules through an α-hemolysin pore as a function of applied voltage. (Less)
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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of chemical physics
volume
117
issue
8
pages
4063 - 4073
publisher
American Institute of Physics (AIP)
external identifiers
  • scopus:0037158591
ISSN
0021-9606
DOI
10.1063/1.1486208
language
English
LU publication?
no
id
772a4dd5-1e54-46f0-8adf-9b4147d50b33
date added to LUP
2019-05-03 11:48:49
date last changed
2022-07-15 14:56:42
@article{772a4dd5-1e54-46f0-8adf-9b4147d50b33,
  abstract     = {{We study the process of charged polymer translocation, driven by an external electric potential, through a narrow pore in a membrane. We assume that the number of polymer segments, m, having passed the entrance pore mouth, is a slow variable governing the translocation process. Outside the pore the probability that there is an end segment at the entrance pore mouth, is taken as the relevant parameter. In particular we derive an expression for the free energy as a function of m, F(m). F(m) is used in the Smoluchowski equation in order to obtain the flux of polymers through the pore. In the low voltage regime we find a thresholdlike behavior and exponential dependence on voltage. Above this regime the flux depends linearly on the applied voltage. At very high voltages the process is diffusion limited and the flux saturates to a constant value. The model accounts for all features of the recent experiments by Henrickson et al. [Phys. Rev. Lett. 85, 3057 (2000)] for the flux of DNA molecules through an α-hemolysin pore as a function of applied voltage.}},
  author       = {{Ambjörnsson, T. and Apell, S. P. and Konkoli, Z. and Di Marzio, E. A. and Kasianowicz, J. J.}},
  issn         = {{0021-9606}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{4063--4073}},
  publisher    = {{American Institute of Physics (AIP)}},
  series       = {{The Journal of chemical physics}},
  title        = {{Charged polymer membrane translocation}},
  url          = {{http://dx.doi.org/10.1063/1.1486208}},
  doi          = {{10.1063/1.1486208}},
  volume       = {{117}},
  year         = {{2002}},
}