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Frequent and long-term follow-up of health-related quality of life following allogeneic haematopoietic stem cell transplantation.

Frödin, U; Lotfi, K; Fomichov, V; Juliusson, Gunnar LU and Börjeson, S (2015) In European Journal of Cancer Care 24(6). p.898-910
Abstract
Health-related quality of life (HRQL) was evaluated in 94 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) after myeloablative (MAC, n = 18) or reduced intensity conditioning (RIC, n = 76). HRQL was assessed with the EORTC QLQ C-30 during the inpatient period as well as during the following 3 years, i.e. at baseline and 12 times thereafter. Functional status and global quality of life decreased from baseline to weeks 2 and 3, especially role and social functions. Symptoms increased significantly during the first 3 weeks, particularly appetite loss, nausea and vomiting, diarrhoea and fatigue. It took at least 1 year for HRQL to return to the baseline level. The only function that improved significantly 3 years... (More)
Health-related quality of life (HRQL) was evaluated in 94 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) after myeloablative (MAC, n = 18) or reduced intensity conditioning (RIC, n = 76). HRQL was assessed with the EORTC QLQ C-30 during the inpatient period as well as during the following 3 years, i.e. at baseline and 12 times thereafter. Functional status and global quality of life decreased from baseline to weeks 2 and 3, especially role and social functions. Symptoms increased significantly during the first 3 weeks, particularly appetite loss, nausea and vomiting, diarrhoea and fatigue. It took at least 1 year for HRQL to return to the baseline level. The only function that improved significantly 3 years after HSCT was role function. Patients treated with MAC experienced significantly worse HRQL at baseline than patients treated with RIC, as well as more pain, sleep disturbance and appetite loss in weeks 3 and 4. Patients with extensive chronic graft-versus-host disease experienced reduced HRQL. These results provide a clinically useful overview of patients' HRQL during and after HSCT and indicate when they require increased support. The results demonstrate the importance of close follow-ups during the first year after HSCT to improve preventive or supportive interventions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer Care
volume
24
issue
6
pages
898 - 910
publisher
John Wiley & Sons
external identifiers
  • pmid:26156141
  • wos:000363466200014
  • scopus:84945445189
ISSN
1365-2354
DOI
10.1111/ecc.12350
language
English
LU publication?
yes
id
851861f6-8ab2-406f-b296-09c6b61b3e1d (old id 7745646)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26156141?dopt=Abstract
date added to LUP
2015-08-10 01:06:04
date last changed
2017-04-23 03:11:15
@article{851861f6-8ab2-406f-b296-09c6b61b3e1d,
  abstract     = {Health-related quality of life (HRQL) was evaluated in 94 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) after myeloablative (MAC, n = 18) or reduced intensity conditioning (RIC, n = 76). HRQL was assessed with the EORTC QLQ C-30 during the inpatient period as well as during the following 3 years, i.e. at baseline and 12 times thereafter. Functional status and global quality of life decreased from baseline to weeks 2 and 3, especially role and social functions. Symptoms increased significantly during the first 3 weeks, particularly appetite loss, nausea and vomiting, diarrhoea and fatigue. It took at least 1 year for HRQL to return to the baseline level. The only function that improved significantly 3 years after HSCT was role function. Patients treated with MAC experienced significantly worse HRQL at baseline than patients treated with RIC, as well as more pain, sleep disturbance and appetite loss in weeks 3 and 4. Patients with extensive chronic graft-versus-host disease experienced reduced HRQL. These results provide a clinically useful overview of patients' HRQL during and after HSCT and indicate when they require increased support. The results demonstrate the importance of close follow-ups during the first year after HSCT to improve preventive or supportive interventions.},
  author       = {Frödin, U and Lotfi, K and Fomichov, V and Juliusson, Gunnar and Börjeson, S},
  issn         = {1365-2354},
  language     = {eng},
  number       = {6},
  pages        = {898--910},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Cancer Care},
  title        = {Frequent and long-term follow-up of health-related quality of life following allogeneic haematopoietic stem cell transplantation.},
  url          = {http://dx.doi.org/10.1111/ecc.12350},
  volume       = {24},
  year         = {2015},
}