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Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source.

Wenz, J; Schleede, S; Khrennikov, K; Bech, Martin LU ; Thibault, P; Heigoldt, M; Pfeiffer, F and Karsch, S (2015) In Nature Communications 6.
Abstract
X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral... (More)
X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral stability. Here we present a phase-contrast microtomogram of a biological sample using betatron X-rays. Comprehensive source characterization enables the reconstruction of absolute electron densities. Our results suggest that laser-based X-ray technology offers the potential for filling the large performance gap between synchrotron- and current X-ray tube-based sources. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
6
publisher
Nature Publishing Group
external identifiers
  • pmid:26189811
  • wos:000358854500001
  • scopus:84937424676
ISSN
2041-1723
DOI
10.1038/ncomms8568
language
English
LU publication?
yes
id
e79d4694-92ca-4b52-8b79-97b9b74b09a2 (old id 7749214)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26189811?dopt=Abstract
date added to LUP
2015-08-10 00:30:05
date last changed
2017-10-22 04:04:53
@article{e79d4694-92ca-4b52-8b79-97b9b74b09a2,
  abstract     = {X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral stability. Here we present a phase-contrast microtomogram of a biological sample using betatron X-rays. Comprehensive source characterization enables the reconstruction of absolute electron densities. Our results suggest that laser-based X-ray technology offers the potential for filling the large performance gap between synchrotron- and current X-ray tube-based sources.},
  articleno    = {7568},
  author       = {Wenz, J and Schleede, S and Khrennikov, K and Bech, Martin and Thibault, P and Heigoldt, M and Pfeiffer, F and Karsch, S},
  issn         = {2041-1723},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Nature Communications},
  title        = {Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source.},
  url          = {http://dx.doi.org/10.1038/ncomms8568},
  volume       = {6},
  year         = {2015},
}