Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source.
Wenz, J ; Schleede, S ; Khrennikov, K ; Bech, Martin LU
; Thibault, P
; Heigoldt, M
; Pfeiffer, F
and Karsch, S
(2015)
In Nature Communications
6.
- Abstract
- X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral... (More)
- X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral stability. Here we present a phase-contrast microtomogram of a biological sample using betatron X-rays. Comprehensive source characterization enables the reconstruction of absolute electron densities. Our results suggest that laser-based X-ray technology offers the potential for filling the large performance gap between synchrotron- and current X-ray tube-based sources. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7749214
- author
- Wenz, J
; Schleede, S
; Khrennikov, K
; Bech, Martin
LU
; Thibault, P
; Heigoldt, M
; Pfeiffer, F
and Karsch, S
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 6
- article number
- 7568
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:26189811
- wos:000358854500001
- scopus:84937424676
- pmid:26189811
- ISSN
- 2041-1723
- DOI
- 10.1038/ncomms8568
- language
- English
- LU publication?
- yes
- id
- e79d4694-92ca-4b52-8b79-97b9b74b09a2 (old id 7749214)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26189811?dopt=Abstract
- date added to LUP
- 2016-04-01 13:19:41
- date last changed
- 2022-04-21 21:03:05
@article{e79d4694-92ca-4b52-8b79-97b9b74b09a2,
abstract = {{X-ray phase-contrast imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imaging, microscopy and materials science. The necessary high spatial coherence is currently provided by either large-scale synchrotron facilities with limited beamtime access or by microfocus X-ray tubes with rather limited flux. X-rays radiated by relativistic electrons driven by well-controlled high-power lasers offer a promising route to a proliferation of this powerful imaging technology. A laser-driven plasma wave accelerates and wiggles electrons, giving rise to a brilliant keV X-ray emission. This so-called betatron radiation is emitted in a collimated beam with excellent spatial coherence and remarkable spectral stability. Here we present a phase-contrast microtomogram of a biological sample using betatron X-rays. Comprehensive source characterization enables the reconstruction of absolute electron densities. Our results suggest that laser-based X-ray technology offers the potential for filling the large performance gap between synchrotron- and current X-ray tube-based sources.}},
author = {{Wenz, J and Schleede, S and Khrennikov, K and Bech, Martin and Thibault, P and Heigoldt, M and Pfeiffer, F and Karsch, S}},
issn = {{2041-1723}},
language = {{eng}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{Quantitative X-ray phase-contrast microtomography from a compact laser-driven betatron source.}},
url = {{http://dx.doi.org/10.1038/ncomms8568}},
doi = {{10.1038/ncomms8568}},
volume = {{6}},
year = {{2015}},
}