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URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.

Aizawa, Naoki; Gandaglia, Giorgio; Hedlund, Petter LU ; Fujimura, Tetsuya; Fukuhara, Hiroshi; Montorsi, Francesco; Homma, Yukio and Igawa, Yasuhiko (2015) In BJU International
Abstract
To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactivity in rats.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BJU International
publisher
Blackwell Science Ltd
external identifiers
  • pmid:26189783
  • scopus:84940173984
  • wos:000374282100024
ISSN
1464-4096
DOI
10.1111/bju.13223
language
English
LU publication?
yes
id
6d7dc4c3-21bb-4153-9645-9dcb539d21fd (old id 7749225)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26189783?dopt=Abstract
date added to LUP
2015-08-09 01:11:26
date last changed
2017-09-24 04:37:47
@article{6d7dc4c3-21bb-4153-9645-9dcb539d21fd,
  abstract     = {To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactivity in rats.},
  author       = {Aizawa, Naoki and Gandaglia, Giorgio and Hedlund, Petter and Fujimura, Tetsuya and Fukuhara, Hiroshi and Montorsi, Francesco and Homma, Yukio and Igawa, Yasuhiko},
  issn         = {1464-4096},
  language     = {eng},
  month        = {07},
  publisher    = {Blackwell Science Ltd},
  series       = {BJU International},
  title        = {URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.},
  url          = {http://dx.doi.org/10.1111/bju.13223},
  year         = {2015},
}