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Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues - Observations in two patients with acromegaly and severe headache.

Marina, Djordje; Burman, Pia LU ; Klose, Marianne; Casar-Borota, Olivera; Luque, Raúl M; Castaño, Justo P and Feldt-Rasmussen, Ulla (2015) In Growth Hormone & Igf Research 25(5). p.262-267
Abstract
Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Growth Hormone & Igf Research
volume
25
issue
5
pages
262 - 267
publisher
Elsevier
external identifiers
  • pmid:26188991
  • wos:000362139000009
  • scopus:84941315068
ISSN
1532-2238
DOI
10.1016/j.ghir.2015.07.003
language
English
LU publication?
yes
id
5a3d29c4-0a7c-4edb-afce-952c34a1672f (old id 7749241)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26188991?dopt=Abstract
date added to LUP
2015-08-10 00:18:13
date last changed
2017-03-19 03:06:21
@article{5a3d29c4-0a7c-4edb-afce-952c34a1672f,
  abstract     = {Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown.},
  author       = {Marina, Djordje and Burman, Pia and Klose, Marianne and Casar-Borota, Olivera and Luque, Raúl M and Castaño, Justo P and Feldt-Rasmussen, Ulla},
  issn         = {1532-2238},
  language     = {eng},
  number       = {5},
  pages        = {262--267},
  publisher    = {Elsevier},
  series       = {Growth Hormone & Igf Research},
  title        = {Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues - Observations in two patients with acromegaly and severe headache.},
  url          = {http://dx.doi.org/10.1016/j.ghir.2015.07.003},
  volume       = {25},
  year         = {2015},
}