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Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues - Observations in two patients with acromegaly and severe headache.

Marina, Djordje ; Burman, Pia LU ; Klose, Marianne ; Casar-Borota, Olivera ; Luque, Raúl M ; Castaño, Justo P and Feldt-Rasmussen, Ulla (2015) In Growth Hormone & Igf Research 25(5). p.262-267
Abstract
Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Growth Hormone & Igf Research
volume
25
issue
5
pages
262 - 267
publisher
Elsevier
external identifiers
  • pmid:26188991
  • wos:000362139000009
  • scopus:84941315068
  • pmid:26188991
ISSN
1532-2238
DOI
10.1016/j.ghir.2015.07.003
language
English
LU publication?
yes
id
5a3d29c4-0a7c-4edb-afce-952c34a1672f (old id 7749241)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26188991?dopt=Abstract
date added to LUP
2016-04-01 10:11:36
date last changed
2025-04-04 14:47:33
@article{5a3d29c4-0a7c-4edb-afce-952c34a1672f,
  abstract     = {{Somatotropinomas have unique "fingerprints" of somatostatin receptor (sst) expression, which are targets in treatment of acromegaly with somatostatin analogues (SSAs). However, a significant expression of sst is not always related to the biochemical response to SSAs. Headache is a common complaint in acromegaly and considered a clinical marker of disease activity. SSAs are reported to have an own analgesic effect, but the sst involved are unknown.}},
  author       = {{Marina, Djordje and Burman, Pia and Klose, Marianne and Casar-Borota, Olivera and Luque, Raúl M and Castaño, Justo P and Feldt-Rasmussen, Ulla}},
  issn         = {{1532-2238}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{262--267}},
  publisher    = {{Elsevier}},
  series       = {{Growth Hormone & Igf Research}},
  title        = {{Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues - Observations in two patients with acromegaly and severe headache.}},
  url          = {{http://dx.doi.org/10.1016/j.ghir.2015.07.003}},
  doi          = {{10.1016/j.ghir.2015.07.003}},
  volume       = {{25}},
  year         = {{2015}},
}