Telomerase activation as a possible mechanism of action for psychopharmacological interventions.
(2015) In Drug Discovery Today 20(11). p.1305-1309- Abstract
- Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or... (More)
- Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or function in the brain and in the periphery could, in turn, represent a neurobiological substrate through which the enzyme can mediate the therapeutic effect of such interventions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7749777
- author
- Bersani, Francesco S ; Lindqvist, Daniel LU ; Mellon, Synthia H ; Penninx, Brenda W J H ; Verhoeven, Josine E ; Révész, Dóra ; Reus, Victor I and Wolkowitz, Owen M
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Drug Discovery Today
- volume
- 20
- issue
- 11
- pages
- 1305 - 1309
- publisher
- Elsevier
- external identifiers
-
- pmid:26166813
- wos:000365369200005
- scopus:84947036673
- pmid:26166813
- ISSN
- 1878-5832
- DOI
- 10.1016/j.drudis.2015.06.016
- language
- English
- LU publication?
- yes
- id
- cfd7d57f-6060-4fcd-b103-77212cd6dec3 (old id 7749777)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26166813?dopt=Abstract
- date added to LUP
- 2016-04-01 10:23:18
- date last changed
- 2022-04-27 21:29:34
@article{cfd7d57f-6060-4fcd-b103-77212cd6dec3,
abstract = {{Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or function in the brain and in the periphery could, in turn, represent a neurobiological substrate through which the enzyme can mediate the therapeutic effect of such interventions.}},
author = {{Bersani, Francesco S and Lindqvist, Daniel and Mellon, Synthia H and Penninx, Brenda W J H and Verhoeven, Josine E and Révész, Dóra and Reus, Victor I and Wolkowitz, Owen M}},
issn = {{1878-5832}},
language = {{eng}},
number = {{11}},
pages = {{1305--1309}},
publisher = {{Elsevier}},
series = {{Drug Discovery Today}},
title = {{Telomerase activation as a possible mechanism of action for psychopharmacological interventions.}},
url = {{http://dx.doi.org/10.1016/j.drudis.2015.06.016}},
doi = {{10.1016/j.drudis.2015.06.016}},
volume = {{20}},
year = {{2015}},
}