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Telomerase activation as a possible mechanism of action for psychopharmacological interventions.

Bersani, Francesco S; Lindqvist, Daniel LU ; Mellon, Synthia H; Penninx, Brenda W J H; Verhoeven, Josine E; Révész, Dóra; Reus, Victor I and Wolkowitz, Owen M (2015) In Drug Discovery Today 20(11). p.1305-1309
Abstract
Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or... (More)
Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or function in the brain and in the periphery could, in turn, represent a neurobiological substrate through which the enzyme can mediate the therapeutic effect of such interventions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Discovery Today
volume
20
issue
11
pages
1305 - 1309
publisher
Elsevier
external identifiers
  • pmid:26166813
  • wos:000365369200005
  • scopus:84947036673
ISSN
1878-5832
DOI
10.1016/j.drudis.2015.06.016
language
English
LU publication?
yes
id
cfd7d57f-6060-4fcd-b103-77212cd6dec3 (old id 7749777)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26166813?dopt=Abstract
date added to LUP
2015-08-08 01:21:48
date last changed
2017-07-23 03:14:26
@article{cfd7d57f-6060-4fcd-b103-77212cd6dec3,
  abstract     = {Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or function in the brain and in the periphery could, in turn, represent a neurobiological substrate through which the enzyme can mediate the therapeutic effect of such interventions.},
  author       = {Bersani, Francesco S and Lindqvist, Daniel and Mellon, Synthia H and Penninx, Brenda W J H and Verhoeven, Josine E and Révész, Dóra and Reus, Victor I and Wolkowitz, Owen M},
  issn         = {1878-5832},
  language     = {eng},
  number       = {11},
  pages        = {1305--1309},
  publisher    = {Elsevier},
  series       = {Drug Discovery Today},
  title        = {Telomerase activation as a possible mechanism of action for psychopharmacological interventions.},
  url          = {http://dx.doi.org/10.1016/j.drudis.2015.06.016},
  volume       = {20},
  year         = {2015},
}