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When is incomplete epigenetic resetting in germ cells favoured by natural selection?

Uller, Tobias LU ; English, Sinead and Pen, Ido (2015) In Proceedings of the Royal Society B: Biological Sciences 282(1811).
Abstract
Resetting of epigenetic marks, such as DNA methylation, in germ cells or early embryos is not always complete. Epigenetic states may therefore persist, decay or accumulate across generations. In spite of mounting empirical evidence for incomplete resetting, it is currently poorly understood whether it simply reflects stochastic noise or plays an adaptive role in phenotype determination. Here, we use a simple model to show that incomplete resetting can be adaptive in heterogeneous environments. Transmission of acquired epigenetic states prevents mismatched phenotypes when the environment changes infrequently relative to generation time and when maternal and environmental cues are unreliable. We discuss how these results may help to... (More)
Resetting of epigenetic marks, such as DNA methylation, in germ cells or early embryos is not always complete. Epigenetic states may therefore persist, decay or accumulate across generations. In spite of mounting empirical evidence for incomplete resetting, it is currently poorly understood whether it simply reflects stochastic noise or plays an adaptive role in phenotype determination. Here, we use a simple model to show that incomplete resetting can be adaptive in heterogeneous environments. Transmission of acquired epigenetic states prevents mismatched phenotypes when the environment changes infrequently relative to generation time and when maternal and environmental cues are unreliable. We discuss how these results may help to interpret the emerging data on transgenerational epigenetic inheritance in plants and animals. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
parental effects, epigenetic inheritance, epigenetic reprogramming, inheritance, transgenerational plasticity, adaptation
in
Proceedings of the Royal Society B: Biological Sciences
volume
282
issue
1811
publisher
Royal Society
external identifiers
  • pmid:26136447
  • wos:000358735700013
  • scopus:84936889301
ISSN
1471-2954
DOI
10.1098/rspb.2015.0682
language
English
LU publication?
yes
id
d0c4d516-e5e4-4990-a0bc-85eb268c75de (old id 7750882)
date added to LUP
2015-09-22 17:42:09
date last changed
2017-11-12 03:37:48
@article{d0c4d516-e5e4-4990-a0bc-85eb268c75de,
  abstract     = {Resetting of epigenetic marks, such as DNA methylation, in germ cells or early embryos is not always complete. Epigenetic states may therefore persist, decay or accumulate across generations. In spite of mounting empirical evidence for incomplete resetting, it is currently poorly understood whether it simply reflects stochastic noise or plays an adaptive role in phenotype determination. Here, we use a simple model to show that incomplete resetting can be adaptive in heterogeneous environments. Transmission of acquired epigenetic states prevents mismatched phenotypes when the environment changes infrequently relative to generation time and when maternal and environmental cues are unreliable. We discuss how these results may help to interpret the emerging data on transgenerational epigenetic inheritance in plants and animals.},
  articleno    = {20150682},
  author       = {Uller, Tobias and English, Sinead and Pen, Ido},
  issn         = {1471-2954},
  keyword      = {parental effects,epigenetic inheritance,epigenetic reprogramming,inheritance,transgenerational plasticity,adaptation},
  language     = {eng},
  number       = {1811},
  publisher    = {Royal Society},
  series       = {Proceedings of the Royal Society B: Biological Sciences},
  title        = {When is incomplete epigenetic resetting in germ cells favoured by natural selection?},
  url          = {http://dx.doi.org/10.1098/rspb.2015.0682},
  volume       = {282},
  year         = {2015},
}