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Polyamine-Dependent Early Cellular Signals and Cell Proliferation

Oredsson, Stina LU (2006) p.41-50
Abstract
When a resting cell is awakened to enter the cell cycle by mitogenic stimulation, a complex molecular machinery involving positive and negative regulation of cell-cycle progression is initiated. Part of the machinery is quite well-known. It involves receptors of various kinds, protein interactions, phosphorylation reactions, and molecular cascades carrying the signal to enter the cell cycle from the cell surface to the nucleus. In the nucleus, transcriptional activation results in an increased involvement of genes in the process. In the cytoplasm, translational and posttranslational mechanisms also have a part in the process. In this complex partly known molecular machinery, there are also molecules that not yet have been assigned a... (More)
When a resting cell is awakened to enter the cell cycle by mitogenic stimulation, a complex molecular machinery involving positive and negative regulation of cell-cycle progression is initiated. Part of the machinery is quite well-known. It involves receptors of various kinds, protein interactions, phosphorylation reactions, and molecular cascades carrying the signal to enter the cell cycle from the cell surface to the nucleus. In the nucleus, transcriptional activation results in an increased involvement of genes in the process. In the cytoplasm, translational and posttranslational mechanisms also have a part in the process. In this complex partly known molecular machinery, there are also molecules that not yet have been assigned a specific role; however, there are enough data to state that their role in normal cell-cycle progression is ubiquitous. The level of the polyamines—putrescine, spermidine, and spermine—are low in nonproliferating cells, but their levels increase early after mitogenic stimulation and these increases are necessary for normal rates of cell-cycle progression (1,2). In this chapter, the focus will be on the role of polyamines in early signaling processes that are required for normal cell-cycle progression. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Polyamine Cell Signaling
editor
Wang, Jian-Ying and Casero, Robert A
pages
41 - 50
publisher
Humana Press
external identifiers
  • scopus:78649965311
ISBN
978-1-59745-145-1
978-1-58829-625-2
DOI
10.1007/978-1-59745-145-1_3
language
English
LU publication?
yes
id
1a3ef10a-0cfc-41a9-bc39-9bb50dc58fac (old id 776341)
date added to LUP
2016-04-04 11:11:07
date last changed
2020-01-12 21:22:20
@inbook{1a3ef10a-0cfc-41a9-bc39-9bb50dc58fac,
  abstract     = {When a resting cell is awakened to enter the cell cycle by mitogenic stimulation, a complex molecular machinery involving positive and negative regulation of cell-cycle progression is initiated. Part of the machinery is quite well-known. It involves receptors of various kinds, protein interactions, phosphorylation reactions, and molecular cascades carrying the signal to enter the cell cycle from the cell surface to the nucleus. In the nucleus, transcriptional activation results in an increased involvement of genes in the process. In the cytoplasm, translational and posttranslational mechanisms also have a part in the process. In this complex partly known molecular machinery, there are also molecules that not yet have been assigned a specific role; however, there are enough data to state that their role in normal cell-cycle progression is ubiquitous. The level of the polyamines—putrescine, spermidine, and spermine—are low in nonproliferating cells, but their levels increase early after mitogenic stimulation and these increases are necessary for normal rates of cell-cycle progression (1,2). In this chapter, the focus will be on the role of polyamines in early signaling processes that are required for normal cell-cycle progression.},
  author       = {Oredsson, Stina},
  booktitle    = {Polyamine Cell Signaling},
  editor       = {Wang, Jian-Ying and Casero, Robert A},
  isbn         = {978-1-59745-145-1},
  language     = {eng},
  pages        = {41--50},
  publisher    = {Humana Press},
  title        = {Polyamine-Dependent Early Cellular Signals and Cell Proliferation},
  url          = {http://dx.doi.org/10.1007/978-1-59745-145-1_3},
  doi          = {10.1007/978-1-59745-145-1_3},
  year         = {2006},
}