A general formalism for metabolic control analysis
(1997) In Chemical Engineering Science 52(15). p.2599-2606- Abstract
- A general formalism for Metabolic Control Analysis is derived using general sensitivity analysis and structural information of the metabolic pathway inherent in the stoichiometry matrix. The equations derived provide a general procedure for calculating the control coefficients from the elasticity coefficients using matrix algebra, and is valid for any pathway stoichiometry. The procedure diminishes the risk of deriving erroneous relations and is, due to its generality, well suited for computer handling. The formalism is mathematically stringent and is a complement to the original theorems of Metabolic Control Analysis, which were derived using ad hoc reasoning. (C) 1997 Elsevier Science Ltd.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3911478
- author
- Ehlde, M and Zacchi, Guido LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Chemical Engineering Science
- volume
- 52
- issue
- 15
- pages
- 2599 - 2606
- publisher
- Elsevier
- external identifiers
-
- wos:A1997XM23200014
- scopus:0031213577
- ISSN
- 0009-2509
- DOI
- 10.1016/S0009-2509(97)00076-6
- language
- English
- LU publication?
- yes
- id
- 778efe70-8136-4100-bda5-c58ec8ff935a (old id 3911478)
- date added to LUP
- 2016-04-01 16:54:59
- date last changed
- 2023-09-05 03:45:22
@article{778efe70-8136-4100-bda5-c58ec8ff935a, abstract = {{A general formalism for Metabolic Control Analysis is derived using general sensitivity analysis and structural information of the metabolic pathway inherent in the stoichiometry matrix. The equations derived provide a general procedure for calculating the control coefficients from the elasticity coefficients using matrix algebra, and is valid for any pathway stoichiometry. The procedure diminishes the risk of deriving erroneous relations and is, due to its generality, well suited for computer handling. The formalism is mathematically stringent and is a complement to the original theorems of Metabolic Control Analysis, which were derived using ad hoc reasoning. (C) 1997 Elsevier Science Ltd.}}, author = {{Ehlde, M and Zacchi, Guido}}, issn = {{0009-2509}}, language = {{eng}}, number = {{15}}, pages = {{2599--2606}}, publisher = {{Elsevier}}, series = {{Chemical Engineering Science}}, title = {{A general formalism for metabolic control analysis}}, url = {{http://dx.doi.org/10.1016/S0009-2509(97)00076-6}}, doi = {{10.1016/S0009-2509(97)00076-6}}, volume = {{52}}, year = {{1997}}, }