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The prognosis of diabetic retinopathy in patients with type 2 diabetes since 1996-1998: the Skaraborg Diabetes Register

Garberg, Grete; Lövestam Adrian, Monica LU ; Nasic, Salmir and Bostrom, Kristina Bengtsson (2015) In International Ophtalmology 35(4). p.503-511
Abstract
Diabetes mellitus is the main reason for visual impairment among patients of working ages. The aim of this paper was to investigate the prognosis of eye complications in patients with diabetes during 10 years of follow-up and contributing risk factors. Data from ophthalmological records (occurrence of retinopathy and laser treatment and visual acuity), and clinical data (blood pressure, glycosylated hemoglobin (HbA1c), body mass index (BMI), and antihypertensive treatment) from the Skaraborg Diabetes Register were retrieved in the Skaraborg Screening Program of 1,258 patients diagnosed during 1996-1998. Kaplan Meyer survival analysis and Log Rank test were used to analyze eye complications in 773 patients with type 2 diabetes and a parts... (More)
Diabetes mellitus is the main reason for visual impairment among patients of working ages. The aim of this paper was to investigate the prognosis of eye complications in patients with diabetes during 10 years of follow-up and contributing risk factors. Data from ophthalmological records (occurrence of retinopathy and laser treatment and visual acuity), and clinical data (blood pressure, glycosylated hemoglobin (HbA1c), body mass index (BMI), and antihypertensive treatment) from the Skaraborg Diabetes Register were retrieved in the Skaraborg Screening Program of 1,258 patients diagnosed during 1996-1998. Kaplan Meyer survival analysis and Log Rank test were used to analyze eye complications in 773 patients with type 2 diabetes and a parts per thousand currency sign70 years at diagnosis. Visual acuity was above the limit for driving license in 96 % of 548 patients and only nineteen patients were treated by laser. At diagnosis of diabetes, mean HbA1c was 6.7 +/- A 1.7 % (59 +/- A 7.1 mmol/mol), and systolic blood pressure was 142.9 +/- A 0.7 mmHg; neither changed significantly during follow-up. Retinopathy appeared about 1 year, and maculopathy 2 years earlier, if HbA1c a parts per thousand yen 7 % (63 mmol/mol) at diagnosis (p < 0.001 and p < 0.006). Antihypertensive treatment, higher BMI, and higher age at diagnosis were associated with less retinopathy during follow-up. Most patients with diabetes develop little retinopathy for the first 10 years after diagnosis. High HbA1c at baseline was associated with retinopathy and maculopathy during follow-up. Antihypertensive treatment, probably a proxy for regular controls and early detection of diabetes, was associated with less retinopathy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Ophtalmology
volume
35
issue
4
pages
503 - 511
publisher
Springer
external identifiers
  • wos:000357287700008
  • scopus:84906031061
ISSN
1573-2630
DOI
10.1007/s10792-014-9976-y
language
English
LU publication?
yes
id
c2c04196-5d96-4f7f-bc9e-7aaf9846e243 (old id 7791016)
date added to LUP
2015-09-01 16:10:06
date last changed
2017-08-20 03:04:07
@article{c2c04196-5d96-4f7f-bc9e-7aaf9846e243,
  abstract     = {Diabetes mellitus is the main reason for visual impairment among patients of working ages. The aim of this paper was to investigate the prognosis of eye complications in patients with diabetes during 10 years of follow-up and contributing risk factors. Data from ophthalmological records (occurrence of retinopathy and laser treatment and visual acuity), and clinical data (blood pressure, glycosylated hemoglobin (HbA1c), body mass index (BMI), and antihypertensive treatment) from the Skaraborg Diabetes Register were retrieved in the Skaraborg Screening Program of 1,258 patients diagnosed during 1996-1998. Kaplan Meyer survival analysis and Log Rank test were used to analyze eye complications in 773 patients with type 2 diabetes and a parts per thousand currency sign70 years at diagnosis. Visual acuity was above the limit for driving license in 96 % of 548 patients and only nineteen patients were treated by laser. At diagnosis of diabetes, mean HbA1c was 6.7 +/- A 1.7 % (59 +/- A 7.1 mmol/mol), and systolic blood pressure was 142.9 +/- A 0.7 mmHg; neither changed significantly during follow-up. Retinopathy appeared about 1 year, and maculopathy 2 years earlier, if HbA1c a parts per thousand yen 7 % (63 mmol/mol) at diagnosis (p &lt; 0.001 and p &lt; 0.006). Antihypertensive treatment, higher BMI, and higher age at diagnosis were associated with less retinopathy during follow-up. Most patients with diabetes develop little retinopathy for the first 10 years after diagnosis. High HbA1c at baseline was associated with retinopathy and maculopathy during follow-up. Antihypertensive treatment, probably a proxy for regular controls and early detection of diabetes, was associated with less retinopathy.},
  author       = {Garberg, Grete and Lövestam Adrian, Monica and Nasic, Salmir and Bostrom, Kristina Bengtsson},
  issn         = {1573-2630},
  language     = {eng},
  number       = {4},
  pages        = {503--511},
  publisher    = {Springer},
  series       = {International Ophtalmology},
  title        = {The prognosis of diabetic retinopathy in patients with type 2 diabetes since 1996-1998: the Skaraborg Diabetes Register},
  url          = {http://dx.doi.org/10.1007/s10792-014-9976-y},
  volume       = {35},
  year         = {2015},
}