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Impaired compensatory response to hypovolaemic circulatory stress in type 1 diabetes mellitus

Lindenberger, Marcus; Olsen, Henrik LU and Lanne, Toste (2011) In Diabetes & Vascular Disease Research 8(2). p.42-136
Abstract

Diabetes mellitus is associated with decreased haemodynamic stability and reduced tolerance to hypovolaemia. Compensatory haemodynamic responses during experimental hypovolaemia in type 1 diabetes patients with (DMR+) and without (DMR-) retinopathy as well as healthy controls (C) were studied. Lower body negative pressure created hypovolaemic circulatory stress. Volumetric techniques were used to assess the compensatory capacitance response (redistribution of peripheral venous blood to the central circulation) and to assess capillary fluid absorption from tissue to blood. The compensatory capacitance response was 1/3 lower in DMR+ compared with C (p = 0.002) and DMR- (p = 0.01). Net capillary fluid absorption was reduced by one-third in... (More)

Diabetes mellitus is associated with decreased haemodynamic stability and reduced tolerance to hypovolaemia. Compensatory haemodynamic responses during experimental hypovolaemia in type 1 diabetes patients with (DMR+) and without (DMR-) retinopathy as well as healthy controls (C) were studied. Lower body negative pressure created hypovolaemic circulatory stress. Volumetric techniques were used to assess the compensatory capacitance response (redistribution of peripheral venous blood to the central circulation) and to assess capillary fluid absorption from tissue to blood. The compensatory capacitance response was 1/3 lower in DMR+ compared with C (p = 0.002) and DMR- (p = 0.01). Net capillary fluid absorption was reduced by one-third in DMR- and DMR+ compared with C (each p < 0.05). Type 1 diabetes patients with retinopathy demonstrate reduced mobilisation of peripheral venous blood to the central circulation. Furthermore, type 1 diabetes patients present with impaired capillary fluid absorption, which in combination with potentially decreased sympathetic vasoconstriction impedes cardiovascular homeostasis during acute hypovolaemic stress.

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published
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keywords
Adaptation, Physiological, Adult, Analysis of Variance, Blood Volume, Capillaries/metabolism, Capillary Permeability, Case-Control Studies, Diabetes Mellitus, Type 1/blood, Diabetic Retinopathy/blood, Hemodynamics, Humans, Hypovolemia/blood, Lower Body Negative Pressure, Male, Plethysmography, Stress, Physiological, Sweden, Time Factors, Vascular Capacitance, Vasoconstriction, Young Adult
in
Diabetes & Vascular Disease Research
volume
8
issue
2
pages
7 pages
publisher
SAGE Publications Inc.
external identifiers
  • scopus:79959193156
ISSN
1752-8984
DOI
10.1177/1479164111404576
language
English
LU publication?
no
id
77bc5f29-82c3-4ccf-becc-33bd11319ff5
date added to LUP
2019-05-29 09:02:47
date last changed
2019-10-15 07:06:51
@article{77bc5f29-82c3-4ccf-becc-33bd11319ff5,
  abstract     = {<p>Diabetes mellitus is associated with decreased haemodynamic stability and reduced tolerance to hypovolaemia. Compensatory haemodynamic responses during experimental hypovolaemia in type 1 diabetes patients with (DMR+) and without (DMR-) retinopathy as well as healthy controls (C) were studied. Lower body negative pressure created hypovolaemic circulatory stress. Volumetric techniques were used to assess the compensatory capacitance response (redistribution of peripheral venous blood to the central circulation) and to assess capillary fluid absorption from tissue to blood. The compensatory capacitance response was 1/3 lower in DMR+ compared with C (p = 0.002) and DMR- (p = 0.01). Net capillary fluid absorption was reduced by one-third in DMR- and DMR+ compared with C (each p &lt; 0.05). Type 1 diabetes patients with retinopathy demonstrate reduced mobilisation of peripheral venous blood to the central circulation. Furthermore, type 1 diabetes patients present with impaired capillary fluid absorption, which in combination with potentially decreased sympathetic vasoconstriction impedes cardiovascular homeostasis during acute hypovolaemic stress.</p>},
  author       = {Lindenberger, Marcus and Olsen, Henrik and Lanne, Toste},
  issn         = {1752-8984},
  keyword      = {Adaptation, Physiological,Adult,Analysis of Variance,Blood Volume,Capillaries/metabolism,Capillary Permeability,Case-Control Studies,Diabetes Mellitus, Type 1/blood,Diabetic Retinopathy/blood,Hemodynamics,Humans,Hypovolemia/blood,Lower Body Negative Pressure,Male,Plethysmography,Stress, Physiological,Sweden,Time Factors,Vascular Capacitance,Vasoconstriction,Young Adult},
  language     = {eng},
  number       = {2},
  pages        = {42--136},
  publisher    = {SAGE Publications Inc.},
  series       = {Diabetes & Vascular Disease Research},
  title        = {Impaired compensatory response to hypovolaemic circulatory stress in type 1 diabetes mellitus},
  url          = {http://dx.doi.org/10.1177/1479164111404576},
  volume       = {8},
  year         = {2011},
}