A neurotoxin that specifically targets Anopheles mosquitoes
(2019) In Nature Communications 10(1). p.2869-2869- Abstract
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution... (More)
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.
(Less)
- author
- Contreras, Estefania ; Masuyer, Geoffrey ; Qureshi, Nadia ; Chawla, Swati ; Dhillon, Harpal S ; Lee, Han Lim ; Chen, Jianwu ; Stenmark, Pål LU and Gill, Sarjeet S
- organization
- publishing date
- 2019-06-28
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 10
- issue
- 1
- pages
- 2869 - 2869
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85068173930
- pmid:31253776
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-019-10732-w
- language
- English
- LU publication?
- yes
- id
- 77c9a783-779d-423b-abfb-d05e1977373e
- date added to LUP
- 2019-07-03 09:43:30
- date last changed
- 2024-09-04 03:55:20
@article{77c9a783-779d-423b-abfb-d05e1977373e, abstract = {{<p>Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.</p>}}, author = {{Contreras, Estefania and Masuyer, Geoffrey and Qureshi, Nadia and Chawla, Swati and Dhillon, Harpal S and Lee, Han Lim and Chen, Jianwu and Stenmark, Pål and Gill, Sarjeet S}}, issn = {{2041-1723}}, language = {{eng}}, month = {{06}}, number = {{1}}, pages = {{2869--2869}}, publisher = {{Nature Publishing Group}}, series = {{Nature Communications}}, title = {{A neurotoxin that specifically targets Anopheles mosquitoes}}, url = {{http://dx.doi.org/10.1038/s41467-019-10732-w}}, doi = {{10.1038/s41467-019-10732-w}}, volume = {{10}}, year = {{2019}}, }