Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates
(2022) In Antimicrobial Agents and Chemotherapy 66(5).- Abstract
Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa.
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https://lup.lub.lu.se/record/78066f5c-794a-422e-86b6-3bfa19a0df8e
- author
- Karabasevic, Natalija ; Roberts, Jason A. ; Stronach, Luke ; Naicker, Saiyuri ; Wallis, Steven C. ; Sjövall, Fredrik LU and Sime, Fekade
- organization
- publishing date
- 2022-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- combination therapy, Hollow-Fiber Infection Model, Pseudomonas aeruginosa
- in
- Antimicrobial Agents and Chemotherapy
- volume
- 66
- issue
- 5
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:35389238
- scopus:85130506452
- ISSN
- 0066-4804
- DOI
- 10.1128/aac.02140-21
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2022 American Society for Microbiology.
- id
- 78066f5c-794a-422e-86b6-3bfa19a0df8e
- date added to LUP
- 2022-08-18 11:19:30
- date last changed
- 2024-04-16 22:43:06
@article{78066f5c-794a-422e-86b6-3bfa19a0df8e, abstract = {{<p>Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa. </p>}}, author = {{Karabasevic, Natalija and Roberts, Jason A. and Stronach, Luke and Naicker, Saiyuri and Wallis, Steven C. and Sjövall, Fredrik and Sime, Fekade}}, issn = {{0066-4804}}, keywords = {{combination therapy; Hollow-Fiber Infection Model; Pseudomonas aeruginosa}}, language = {{eng}}, number = {{5}}, publisher = {{American Society for Microbiology}}, series = {{Antimicrobial Agents and Chemotherapy}}, title = {{Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates}}, url = {{http://dx.doi.org/10.1128/aac.02140-21}}, doi = {{10.1128/aac.02140-21}}, volume = {{66}}, year = {{2022}}, }