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Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates

Karabasevic, Natalija ; Roberts, Jason A. ; Stronach, Luke ; Naicker, Saiyuri ; Wallis, Steven C. ; Sjövall, Fredrik LU orcid and Sime, Fekade (2022) In Antimicrobial Agents and Chemotherapy 66(5).
Abstract

Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
combination therapy, Hollow-Fiber Infection Model, Pseudomonas aeruginosa
in
Antimicrobial Agents and Chemotherapy
volume
66
issue
5
publisher
American Society for Microbiology
external identifiers
  • pmid:35389238
  • scopus:85130506452
ISSN
0066-4804
DOI
10.1128/aac.02140-21
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022 American Society for Microbiology.
id
78066f5c-794a-422e-86b6-3bfa19a0df8e
date added to LUP
2022-08-18 11:19:30
date last changed
2024-04-16 22:43:06
@article{78066f5c-794a-422e-86b6-3bfa19a0df8e,
  abstract     = {{<p>Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ; 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 108 - 1010 CFU/mL at 120 h. In contrast, combination therapy achieved . 5-log kill within 6 h and suppressed bacterial regrowth throughout. The results suggest that meropenem-ciprofloxacin combination may provide significantly enhanced bacterial killing and resistance suppression against P. aeruginosa. </p>}},
  author       = {{Karabasevic, Natalija and Roberts, Jason A. and Stronach, Luke and Naicker, Saiyuri and Wallis, Steven C. and Sjövall, Fredrik and Sime, Fekade}},
  issn         = {{0066-4804}},
  keywords     = {{combination therapy; Hollow-Fiber Infection Model; Pseudomonas aeruginosa}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Antimicrobial Agents and Chemotherapy}},
  title        = {{Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates}},
  url          = {{http://dx.doi.org/10.1128/aac.02140-21}},
  doi          = {{10.1128/aac.02140-21}},
  volume       = {{66}},
  year         = {{2022}},
}