Supported liquid membrane work-up of blood plasma samples coupled on-line to liquid chromatographic determination of basic antidepressant drugs
(2004) In Chromatographia 59(3-4). p.161-165- Abstract
- An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment, has been developed. The chromatograms after enrichment of plasma blank and aqueous blank are virtually indistinguishable. The entire analytical procedure revealed good linearity and low detection limits of 5, 15 and 20 ng mL(-1) for dibenzepine, reboxetine and fluvoxamine, respectively. No carry-over effects were noted. The repeatability of... (More)
- An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment, has been developed. The chromatograms after enrichment of plasma blank and aqueous blank are virtually indistinguishable. The entire analytical procedure revealed good linearity and low detection limits of 5, 15 and 20 ng mL(-1) for dibenzepine, reboxetine and fluvoxamine, respectively. No carry-over effects were noted. The repeatability of extraction at three concentrations in the range 40-150 ng mL(-1) for the three drugs was between ca. 3% and 7% as relative standard deviation. The reproducibility relative standard deviation during three different days (replacing the membrane each day) was not significantly higher. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/138386
- author
- Barri, Thaer LU and Jönsson, Jan Åke LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Chromatographia
- volume
- 59
- issue
- 3-4
- pages
- 161 - 165
- publisher
- Vieweg Verlag
- external identifiers
-
- wos:000224099700003
- scopus:1442300890
- ISSN
- 0009-5893
- DOI
- 10.1365/s10337-003-0147-y
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)
- id
- 7812a49d-ecfb-41f3-8127-5808ed85932b (old id 138386)
- date added to LUP
- 2016-04-01 17:07:51
- date last changed
- 2022-03-30 20:42:01
@article{7812a49d-ecfb-41f3-8127-5808ed85932b, abstract = {{An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment, has been developed. The chromatograms after enrichment of plasma blank and aqueous blank are virtually indistinguishable. The entire analytical procedure revealed good linearity and low detection limits of 5, 15 and 20 ng mL(-1) for dibenzepine, reboxetine and fluvoxamine, respectively. No carry-over effects were noted. The repeatability of extraction at three concentrations in the range 40-150 ng mL(-1) for the three drugs was between ca. 3% and 7% as relative standard deviation. The reproducibility relative standard deviation during three different days (replacing the membrane each day) was not significantly higher.}}, author = {{Barri, Thaer and Jönsson, Jan Åke}}, issn = {{0009-5893}}, language = {{eng}}, number = {{3-4}}, pages = {{161--165}}, publisher = {{Vieweg Verlag}}, series = {{Chromatographia}}, title = {{Supported liquid membrane work-up of blood plasma samples coupled on-line to liquid chromatographic determination of basic antidepressant drugs}}, url = {{http://dx.doi.org/10.1365/s10337-003-0147-y}}, doi = {{10.1365/s10337-003-0147-y}}, volume = {{59}}, year = {{2004}}, }