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Use test with l-carvone in toothpaste on sensitized individuals

Kroona, Liv ; Ahlgren, Camilla ; Dahlin, Jakob LU ; Isaksson, Marléne LU and Bruze, Magnus LU (2023) In Contact Dermatitis 88(6). p.463-471
Abstract

Background: The mint flavour carvone (l-carvone) is considered a weak contact allergen. However, contact allergy to carvone is more prevalent in patients with oral lichen planus or oral lichenoid lesions (OLP/OLL). Objective: Our aim was to investigate how carvone affects sensitized individuals through a use test with toothpaste containing carvone. Non-flavoured toothpaste served as control. Methods: Subjects were patch tested prior to the use test—14 subjects allergic to carvone (11 with OLP/OLL), 20 subjects with OLP/OLL and 3 healthy controls. The month-long use test comprised of using toothpaste twice daily. Subjects were examined fortnightly. Clinical signs were assessed with a mucosal scoring system. The subjects' oral... (More)

Background: The mint flavour carvone (l-carvone) is considered a weak contact allergen. However, contact allergy to carvone is more prevalent in patients with oral lichen planus or oral lichenoid lesions (OLP/OLL). Objective: Our aim was to investigate how carvone affects sensitized individuals through a use test with toothpaste containing carvone. Non-flavoured toothpaste served as control. Methods: Subjects were patch tested prior to the use test—14 subjects allergic to carvone (11 with OLP/OLL), 20 subjects with OLP/OLL and 3 healthy controls. The month-long use test comprised of using toothpaste twice daily. Subjects were examined fortnightly. Clinical signs were assessed with a mucosal scoring system. The subjects' oral health-related quality of life was measured with the oral health impact profile (OHIP-49). Results: Local reactions to the carvone toothpaste presented as aggravated OLL (7/10) and peri-oral eczema (2/10) in allergic subjects. They also had significantly higher mucosal and OHIP scores compared with those receiving non-flavoured toothpaste. Conclusion: In sensitized individuals, oral exposure to carvone gives aggravated oral lesions and/or peri-oral eczema. The lesions mimic OLP and allergic individuals are therefore at risk of not being assessed with regard to flavour contact allergy.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
contact cheilitis, contact stomatitis, l-carvone, mucosal score, OHIP-49, oral lichen planus, oral lichenoid lesion, toothpaste, use test
in
Contact Dermatitis
volume
88
issue
6
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:36929649
  • scopus:85150807683
ISSN
0105-1873
DOI
10.1111/cod.14302
language
English
LU publication?
yes
id
78148527-0cc8-4ff9-a8ef-a5970afd49e0
date added to LUP
2023-05-26 14:39:32
date last changed
2024-06-29 04:38:04
@article{78148527-0cc8-4ff9-a8ef-a5970afd49e0,
  abstract     = {{<p>Background: The mint flavour carvone (l-carvone) is considered a weak contact allergen. However, contact allergy to carvone is more prevalent in patients with oral lichen planus or oral lichenoid lesions (OLP/OLL). Objective: Our aim was to investigate how carvone affects sensitized individuals through a use test with toothpaste containing carvone. Non-flavoured toothpaste served as control. Methods: Subjects were patch tested prior to the use test—14 subjects allergic to carvone (11 with OLP/OLL), 20 subjects with OLP/OLL and 3 healthy controls. The month-long use test comprised of using toothpaste twice daily. Subjects were examined fortnightly. Clinical signs were assessed with a mucosal scoring system. The subjects' oral health-related quality of life was measured with the oral health impact profile (OHIP-49). Results: Local reactions to the carvone toothpaste presented as aggravated OLL (7/10) and peri-oral eczema (2/10) in allergic subjects. They also had significantly higher mucosal and OHIP scores compared with those receiving non-flavoured toothpaste. Conclusion: In sensitized individuals, oral exposure to carvone gives aggravated oral lesions and/or peri-oral eczema. The lesions mimic OLP and allergic individuals are therefore at risk of not being assessed with regard to flavour contact allergy.</p>}},
  author       = {{Kroona, Liv and Ahlgren, Camilla and Dahlin, Jakob and Isaksson, Marléne and Bruze, Magnus}},
  issn         = {{0105-1873}},
  keywords     = {{contact cheilitis; contact stomatitis; l-carvone; mucosal score; OHIP-49; oral lichen planus; oral lichenoid lesion; toothpaste; use test}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{463--471}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Use test with l-carvone in toothpaste on sensitized individuals}},
  url          = {{http://dx.doi.org/10.1111/cod.14302}},
  doi          = {{10.1111/cod.14302}},
  volume       = {{88}},
  year         = {{2023}},
}