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Broad spectrum antimicrobial compounds from the bacterium Exiguobacterium mexicanum MSSRFS9.

Shanthakumar, S P; Duraisamy, Purushothaman; Vishwanath, Ganga; Selvanesan, Benson LU ; Ramaraj, Vijayakumar and Vasantharaj David, B (2015) In Microbiological Research 178. p.59-65
Abstract
Clinical bacterial pathogens front a major challenge for the clinical researchers and physicians. In particular microbial pathogens like Escherichia coli, Shigella flexneri, Klebsiella pneumonia and Salmonella enterica are apparelled with systemic machineries to bring down the human immune system as well as proliferate dramatically in a short period which in turn cause a pronounced ailment to the human health. In vitro evaluation of four purified compounds isolated from rhizosphere bacterium Exiguobacterium mexicanum tested against clinical pathogens mentioned above by disc diffusion method showed the two compounds viz., 3,6,18-trione, 9,10-dihydro-12'-hydroxyl-2methyl-5-(phenyl methyl) (5'-alpha, 10-alpha)-dihydroergotamine (C3) and... (More)
Clinical bacterial pathogens front a major challenge for the clinical researchers and physicians. In particular microbial pathogens like Escherichia coli, Shigella flexneri, Klebsiella pneumonia and Salmonella enterica are apparelled with systemic machineries to bring down the human immune system as well as proliferate dramatically in a short period which in turn cause a pronounced ailment to the human health. In vitro evaluation of four purified compounds isolated from rhizosphere bacterium Exiguobacterium mexicanum tested against clinical pathogens mentioned above by disc diffusion method showed the two compounds viz., 3,6,18-trione, 9,10-dihydro-12'-hydroxyl-2methyl-5-(phenyl methyl) (5'-alpha, 10-alpha)-dihydroergotamine (C3) and dipropyl - S-propyl ester (C4) exhibit antibacterial property against all the tested pathogens. Among the four clinical pathogens tested, compound C3 has shown higher zone of inhibition against S. enterica with 17±0mm, followed by S. flexneri with 16.5±0.7mm, E. coli with 15±0mm and K. pneumoniae with 14±0mm, respectively. The compound C4 has shown higher antimicrobial activity against S. enterica with 21.5±0.7mm zone of inhibition, followed by S. flexneri with 19.5±0.7mm, E. coli with 17±0mm and K. pneumoniae with 16±0mm, these two compounds were found to be safer when subjected to rat haematological and enzymatic analysis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbiological Research
volume
178
pages
59 - 65
publisher
Urban & Fischer Verlag
external identifiers
  • pmid:26302848
  • wos:000361414400008
  • scopus:84939796785
ISSN
1618-0623
DOI
10.1016/j.micres.2015.06.007
language
English
LU publication?
yes
id
0e6ed152-c320-4f47-8fbe-af473700dab1 (old id 7835007)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26302848?dopt=Abstract
date added to LUP
2015-09-07 19:15:34
date last changed
2017-10-01 03:32:31
@article{0e6ed152-c320-4f47-8fbe-af473700dab1,
  abstract     = {Clinical bacterial pathogens front a major challenge for the clinical researchers and physicians. In particular microbial pathogens like Escherichia coli, Shigella flexneri, Klebsiella pneumonia and Salmonella enterica are apparelled with systemic machineries to bring down the human immune system as well as proliferate dramatically in a short period which in turn cause a pronounced ailment to the human health. In vitro evaluation of four purified compounds isolated from rhizosphere bacterium Exiguobacterium mexicanum tested against clinical pathogens mentioned above by disc diffusion method showed the two compounds viz., 3,6,18-trione, 9,10-dihydro-12'-hydroxyl-2methyl-5-(phenyl methyl) (5'-alpha, 10-alpha)-dihydroergotamine (C3) and dipropyl - S-propyl ester (C4) exhibit antibacterial property against all the tested pathogens. Among the four clinical pathogens tested, compound C3 has shown higher zone of inhibition against S. enterica with 17±0mm, followed by S. flexneri with 16.5±0.7mm, E. coli with 15±0mm and K. pneumoniae with 14±0mm, respectively. The compound C4 has shown higher antimicrobial activity against S. enterica with 21.5±0.7mm zone of inhibition, followed by S. flexneri with 19.5±0.7mm, E. coli with 17±0mm and K. pneumoniae with 16±0mm, these two compounds were found to be safer when subjected to rat haematological and enzymatic analysis.},
  author       = {Shanthakumar, S P and Duraisamy, Purushothaman and Vishwanath, Ganga and Selvanesan, Benson and Ramaraj, Vijayakumar and Vasantharaj David, B},
  issn         = {1618-0623},
  language     = {eng},
  pages        = {59--65},
  publisher    = {Urban & Fischer Verlag},
  series       = {Microbiological Research},
  title        = {Broad spectrum antimicrobial compounds from the bacterium Exiguobacterium mexicanum MSSRFS9.},
  url          = {http://dx.doi.org/10.1016/j.micres.2015.06.007},
  volume       = {178},
  year         = {2015},
}