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Chimerism analysis in clinical practice and its relevance for the detection of graft rejection and malignant relapse in pediatric hematopoietic stem cell transplant patients.

Mellgren, Karin; Arvidson, Johan; Toporski, Jacek LU and Winiarski, Jacek (2015) In Pediatric Transplantation 19(7). p.758-766
Abstract
Chimerism and clinical outcome data from 244 hematopoietic stem cell transplants in 218 children were retrospectively analyzed to assess their relevance for the detection of graft rejection and malignant relapse. Patients transplanted for a non-malignant disease had significantly higher proportions of residual recipient T cells in peripheral blood at one, three, and six months compared with patients transplanted for malignant disease. Recipient T-cell levels were below 50% at one month after transplantation in most patients (129 of 152 transplants). Graft rejection occurred more frequently in the group of patients with high levels of recipient cells at one month (10 graft rejections in the 23 patients with recipient T cells >50% at one... (More)
Chimerism and clinical outcome data from 244 hematopoietic stem cell transplants in 218 children were retrospectively analyzed to assess their relevance for the detection of graft rejection and malignant relapse. Patients transplanted for a non-malignant disease had significantly higher proportions of residual recipient T cells in peripheral blood at one, three, and six months compared with patients transplanted for malignant disease. Recipient T-cell levels were below 50% at one month after transplantation in most patients (129 of 152 transplants). Graft rejection occurred more frequently in the group of patients with high levels of recipient cells at one month (10 graft rejections in the 23 patients with recipient T cells >50% at one month as compared to seven graft rejections occurred in 129 patients with recipient T cells <50% (p < 0.001). Multilineage chimerism data in 87 children with leukemia at one, three, and six months after transplantation were not correlated with subsequent relapse of malignant disease. In conclusion, early analysis of lineage-specific chimerism in peripheral blood can be used to identify patients who are at high risk of graft rejection. However, the efficacy of early chimerism analysis for predicting leukemia relapse was limited. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Transplantation
volume
19
issue
7
pages
758 - 766
publisher
Wiley-Blackwell
external identifiers
  • pmid:26290161
  • wos:000362580100022
  • scopus:84973487055
ISSN
1399-3046
DOI
10.1111/petr.12580
language
English
LU publication?
no
id
615d01ef-c745-41ce-b5a9-4b2b63435397 (old id 7840546)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26290161?dopt=Abstract
date added to LUP
2015-09-06 15:09:26
date last changed
2017-01-01 03:15:15
@article{615d01ef-c745-41ce-b5a9-4b2b63435397,
  abstract     = {Chimerism and clinical outcome data from 244 hematopoietic stem cell transplants in 218 children were retrospectively analyzed to assess their relevance for the detection of graft rejection and malignant relapse. Patients transplanted for a non-malignant disease had significantly higher proportions of residual recipient T cells in peripheral blood at one, three, and six months compared with patients transplanted for malignant disease. Recipient T-cell levels were below 50% at one month after transplantation in most patients (129 of 152 transplants). Graft rejection occurred more frequently in the group of patients with high levels of recipient cells at one month (10 graft rejections in the 23 patients with recipient T cells &gt;50% at one month as compared to seven graft rejections occurred in 129 patients with recipient T cells &lt;50% (p &lt; 0.001). Multilineage chimerism data in 87 children with leukemia at one, three, and six months after transplantation were not correlated with subsequent relapse of malignant disease. In conclusion, early analysis of lineage-specific chimerism in peripheral blood can be used to identify patients who are at high risk of graft rejection. However, the efficacy of early chimerism analysis for predicting leukemia relapse was limited.},
  author       = {Mellgren, Karin and Arvidson, Johan and Toporski, Jacek and Winiarski, Jacek},
  issn         = {1399-3046},
  language     = {eng},
  number       = {7},
  pages        = {758--766},
  publisher    = {Wiley-Blackwell},
  series       = {Pediatric Transplantation},
  title        = {Chimerism analysis in clinical practice and its relevance for the detection of graft rejection and malignant relapse in pediatric hematopoietic stem cell transplant patients.},
  url          = {http://dx.doi.org/10.1111/petr.12580},
  volume       = {19},
  year         = {2015},
}