Common genetic risk factors for coronary artery disease: new opportunities for prevention?
Hamrefors, Viktor LU
(2015)
In Clinical Physiology and Functional Imaging
- Abstract
- Atherosclerotic cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide, with coronary artery disease (CAD) being the single leading cause of death. Better control of risk factors, enhanced diagnostic techniques and improved medical therapies have all substantially decreased the mortality of CAD in developed countries. However, CAD and other forms of atherosclerotic CVD are projected to remain the leading cause of death by 2030 and we face a number of challenges if the outcomes of CAD are to be further improved. The fact that a substantial fraction of high-risk subjects do not reach treatment goals for important risk factors is one of these challenges. At the same time, there is also a non-negotiable fraction... (More)
- Atherosclerotic cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide, with coronary artery disease (CAD) being the single leading cause of death. Better control of risk factors, enhanced diagnostic techniques and improved medical therapies have all substantially decreased the mortality of CAD in developed countries. However, CAD and other forms of atherosclerotic CVD are projected to remain the leading cause of death by 2030 and we face a number of challenges if the outcomes of CAD are to be further improved. The fact that a substantial fraction of high-risk subjects do not reach treatment goals for important risk factors is one of these challenges. At the same time, there is also a non-negotiable fraction of 'concealed' high-risk subjects who are not detected by current risk algorithms and diagnostic modalities. In recent years, we have started to rapidly increase our knowledge of the framework of common genetics underlying CAD and atherosclerotic CVD in the population. In conjunction with modern diagnostic and therapeutic options, this new genetic knowledge may provide a valuable tool for further improvements in prevention. This review summarizes the recent findings from the search for common genetic risk factors for CAD. Furthermore, the author discusses how such recent findings could potentially be used in a number of clinical applications within CAD prevention, including in clinical risk stratification, in prediction of drug treatment response and in the search for targets for novel preventive therapies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7840790
- author
- Hamrefors, Viktor
LU
- organization
- publishing date
- 2015-08-17
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Physiology and Functional Imaging
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:26278888
- scopus:84940182383
- pmid:26278888
- wos:000398893400002
- ISSN
- 1475-0961
- DOI
- 10.1111/cpf.12289
- language
- English
- LU publication?
- yes
- id
- 873bed78-b471-487c-877f-db01676fe7ad (old id 7840790)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26278888?dopt=Abstract
- date added to LUP
- 2016-04-01 09:51:48
- date last changed
- 2023-11-09 06:05:42
@article{873bed78-b471-487c-877f-db01676fe7ad,
abstract = {{Atherosclerotic cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide, with coronary artery disease (CAD) being the single leading cause of death. Better control of risk factors, enhanced diagnostic techniques and improved medical therapies have all substantially decreased the mortality of CAD in developed countries. However, CAD and other forms of atherosclerotic CVD are projected to remain the leading cause of death by 2030 and we face a number of challenges if the outcomes of CAD are to be further improved. The fact that a substantial fraction of high-risk subjects do not reach treatment goals for important risk factors is one of these challenges. At the same time, there is also a non-negotiable fraction of 'concealed' high-risk subjects who are not detected by current risk algorithms and diagnostic modalities. In recent years, we have started to rapidly increase our knowledge of the framework of common genetics underlying CAD and atherosclerotic CVD in the population. In conjunction with modern diagnostic and therapeutic options, this new genetic knowledge may provide a valuable tool for further improvements in prevention. This review summarizes the recent findings from the search for common genetic risk factors for CAD. Furthermore, the author discusses how such recent findings could potentially be used in a number of clinical applications within CAD prevention, including in clinical risk stratification, in prediction of drug treatment response and in the search for targets for novel preventive therapies.}},
author = {{Hamrefors, Viktor}},
issn = {{1475-0961}},
language = {{eng}},
month = {{08}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Clinical Physiology and Functional Imaging}},
title = {{Common genetic risk factors for coronary artery disease: new opportunities for prevention?}},
url = {{http://dx.doi.org/10.1111/cpf.12289}},
doi = {{10.1111/cpf.12289}},
year = {{2015}},
}