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Ubiquitous Structural Signaling in Bacterial Phytochromes.

Björling, Alexander; Berntsson, Oskar; Takala, Heikki; Gallagher, Kevin D; Patel, Hardik; Gustavsson, Emil; St Peter, Rachael; Duong, Phu; Nugent, Angela and Zhang, Fan, et al. (2015) In The Journal of Physical Chemistry Letters 6(17). p.3379-3383
Abstract
The phytochrome family of light-switchable proteins has long been studied by biochemical, spectroscopic and crystallographic means, while a direct probe for global conformational signal propagation has been lacking. Using solution X-ray scattering, we find that the photosensory cores of several bacterial phytochromes undergo similar large-scale structural changes upon red-light excitation. The data establish that phytochromes with ordinary and inverted photocycles share a structural signaling mechanism and that a particular conserved histidine, previously proposed to be involved in signal propagation, in fact tunes photoresponse.
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Contribution to journal
publication status
published
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The Journal of Physical Chemistry Letters
volume
6
issue
17
pages
3379 - 3383
publisher
The American Chemical Society
external identifiers
  • pmid:26275765
  • wos:000360953300010
  • scopus:84942606333
ISSN
1948-7185
DOI
10.1021/acs.jpclett.5b01629
language
English
LU publication?
yes
id
a14602b1-2bee-48f7-8ae5-3461da664bd9 (old id 7841023)
date added to LUP
2015-09-10 20:11:21
date last changed
2017-10-01 04:07:40
@article{a14602b1-2bee-48f7-8ae5-3461da664bd9,
  abstract     = {The phytochrome family of light-switchable proteins has long been studied by biochemical, spectroscopic and crystallographic means, while a direct probe for global conformational signal propagation has been lacking. Using solution X-ray scattering, we find that the photosensory cores of several bacterial phytochromes undergo similar large-scale structural changes upon red-light excitation. The data establish that phytochromes with ordinary and inverted photocycles share a structural signaling mechanism and that a particular conserved histidine, previously proposed to be involved in signal propagation, in fact tunes photoresponse.},
  author       = {Björling, Alexander and Berntsson, Oskar and Takala, Heikki and Gallagher, Kevin D and Patel, Hardik and Gustavsson, Emil and St Peter, Rachael and Duong, Phu and Nugent, Angela and Zhang, Fan and Berntsen, Peter and Appio, Roberto and Rajkovic, Ivan and Lehtivuori, Heli and Panman, Matthijs R and Hoernke, Maria and Niebling, Stephan and Harimoorthy, Rajiv and Lamparter, Tilman and Stojković, Emina A and Ihalainen, Janne A and Westenhoff, Sebastian},
  issn         = {1948-7185},
  language     = {eng},
  number       = {17},
  pages        = {3379--3383},
  publisher    = {The American Chemical Society},
  series       = {The Journal of Physical Chemistry Letters},
  title        = {Ubiquitous Structural Signaling in Bacterial Phytochromes.},
  url          = {http://dx.doi.org/10.1021/acs.jpclett.5b01629},
  volume       = {6},
  year         = {2015},
}