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Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: Secondary analysis of the Euro-Ewing99-R1 trial.

van den Berg, Henk; Paulussen, Michael; Le Teuff, Gwénaël; Judson, Ian; Gelderblom, Hans; Dirksen, Uta; Brennan, Bernadette; Whelan, Jeremy; Ladenstein, Ruth Lydia and Marec-Berard, Perrine, et al. (2015) In European Journal of Cancer 51(16). p.2453-2464
Abstract
Based on the randomised Euro-EWING99-R1 trial, vincristine, adriamycin, cyclophosphamide (VAC) may be able to replace vincristine, adriamycin, ifosfamide (VAI) in the treatment of standard-risk Ewing sarcoma. However some heterogeneity of treatment effect by gender was observed. The current exploratory study aimed at investigating the influence of gender on treatment efficacy and acute toxicity.
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Contribution to journal
publication status
published
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in
European Journal of Cancer
volume
51
issue
16
pages
2453 - 2464
publisher
IFAC & Elsevier Ltd.
external identifiers
  • pmid:26271204
  • wos:000363466800021
  • scopus:84943661094
ISSN
1879-0852
DOI
10.1016/j.ejca.2015.06.123
language
English
LU publication?
yes
id
df3393eb-2b83-411e-aee2-676be8319993 (old id 7841180)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26271204?dopt=Abstract
date added to LUP
2015-09-05 18:44:37
date last changed
2017-08-13 03:18:47
@article{df3393eb-2b83-411e-aee2-676be8319993,
  abstract     = {Based on the randomised Euro-EWING99-R1 trial, vincristine, adriamycin, cyclophosphamide (VAC) may be able to replace vincristine, adriamycin, ifosfamide (VAI) in the treatment of standard-risk Ewing sarcoma. However some heterogeneity of treatment effect by gender was observed. The current exploratory study aimed at investigating the influence of gender on treatment efficacy and acute toxicity.},
  author       = {van den Berg, Henk and Paulussen, Michael and Le Teuff, Gwénaël and Judson, Ian and Gelderblom, Hans and Dirksen, Uta and Brennan, Bernadette and Whelan, Jeremy and Ladenstein, Ruth Lydia and Marec-Berard, Perrine and Kruseova, Jarmila and Hjorth, Lars and Kühne, Thomas and Brichard, Benedicte and Wheatley, Keith and Craft, Alan and Juergens, Heribert and Gaspar, Nathalie and Le Deley, Marie-Cécile},
  issn         = {1879-0852},
  language     = {eng},
  number       = {16},
  pages        = {2453--2464},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: Secondary analysis of the Euro-Ewing99-R1 trial.},
  url          = {http://dx.doi.org/10.1016/j.ejca.2015.06.123},
  volume       = {51},
  year         = {2015},
}