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New circulating biomarkers for predicting cardiovascular death in healthy population.

Melander, Olle LU ; Modrego, Javier; Zamorano-León, Jose J; Santos-Sancho, Juana M; Lahera, Vicente and López-Farré, Antonio J (2015) In Journal of Cellular and Molecular Medicine 19(10). p.2489-2499
Abstract
There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. The study was performed in 82 individuals from the Malmö Diet and Cancer study cohort, free from CVD of whom 41 developed CVD and 41 did not. Plasma proteins related to inflammation and thrombo-coagulating processes were analysed. α1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute... (More)
There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. The study was performed in 82 individuals from the Malmö Diet and Cancer study cohort, free from CVD of whom 41 developed CVD and 41 did not. Plasma proteins related to inflammation and thrombo-coagulating processes were analysed. α1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute cardiovascular episode. Of 82 participants, 17 died by CVD causes. There were proteins whose expression in plasma was significantly higher in participants suffering CVD death as compared with those that did not die by CVD. These proteins included: fibrinogen β-chain isotypes 1 and 3, fibrinogen-γ-chain isotype 2, vitamin D-binding protein isotypes 1, 2 and 3, α1-antitrypsin isotypes 3 and 6, haptoglobin isotypes 3,4,5 and 5, haemopexin isotypes 1 and 2, and Rho/Rac guanine nucleotide exchange factor 2. Moreover, apolipoprotein J plasma levels were found lower in participants that died by cardiovascular cause. Association between plasma levels of proteins and CVD death was independent of age, gender, conventional risk factors and plasma C-reactive protein levels. Several protein plasma levels and protein isotypes related to inflammation and thrombo-coagulating phenomena were independently associated with the risk of future CVD death. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Cellular and Molecular Medicine
volume
19
issue
10
pages
2489 - 2499
publisher
Wiley-Blackwell
external identifiers
  • pmid:26258425
  • wos:000362222800018
  • scopus:84942370469
ISSN
1582-1838
DOI
10.1111/jcmm.12652
language
English
LU publication?
yes
id
57541760-5165-4525-88e6-7aca24a09061 (old id 7844293)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26258425?dopt=Abstract
date added to LUP
2015-09-05 16:37:15
date last changed
2017-07-30 03:06:29
@article{57541760-5165-4525-88e6-7aca24a09061,
  abstract     = {There is interest to analyse newer biomarkers to identify healthy individuals at risk to develop cardiovascular disease (CVD) incidents and death. To determine in healthy individuals new circulating protein biomarkers, whose systemic levels may be associated with the risk of future development of CVD incidents and death. The study was performed in 82 individuals from the Malmö Diet and Cancer study cohort, free from CVD of whom 41 developed CVD and 41 did not. Plasma proteins related to inflammation and thrombo-coagulating processes were analysed. α1-antitrypsin isotype 3 plasma levels were significantly higher while apolipoprotein J plasma levels were lower in participants that developed CVD incidents than those that did not develop acute cardiovascular episode. Of 82 participants, 17 died by CVD causes. There were proteins whose expression in plasma was significantly higher in participants suffering CVD death as compared with those that did not die by CVD. These proteins included: fibrinogen β-chain isotypes 1 and 3, fibrinogen-γ-chain isotype 2, vitamin D-binding protein isotypes 1, 2 and 3, α1-antitrypsin isotypes 3 and 6, haptoglobin isotypes 3,4,5 and 5, haemopexin isotypes 1 and 2, and Rho/Rac guanine nucleotide exchange factor 2. Moreover, apolipoprotein J plasma levels were found lower in participants that died by cardiovascular cause. Association between plasma levels of proteins and CVD death was independent of age, gender, conventional risk factors and plasma C-reactive protein levels. Several protein plasma levels and protein isotypes related to inflammation and thrombo-coagulating phenomena were independently associated with the risk of future CVD death.},
  author       = {Melander, Olle and Modrego, Javier and Zamorano-León, Jose J and Santos-Sancho, Juana M and Lahera, Vicente and López-Farré, Antonio J},
  issn         = {1582-1838},
  language     = {eng},
  number       = {10},
  pages        = {2489--2499},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Cellular and Molecular Medicine},
  title        = {New circulating biomarkers for predicting cardiovascular death in healthy population.},
  url          = {http://dx.doi.org/10.1111/jcmm.12652},
  volume       = {19},
  year         = {2015},
}