Advanced

Genetic predisposition to weight loss & regain with lifestyle intervention: analyses from the Diabetes Prevention Program & the Look AHEAD randomized controlled trials.

Papandonatos, George D; Pan, Qing; Pajewski, Nicholas M; Delahanty, Linda M; Peter, Inga; Erar, Bahar; Ahmad, Shafqat LU ; Harden, Maegan; Chen, Ling and Fontanillas, Pierre, et al. (2015) In Diabetes 64(12). p.4312-4321
Abstract
Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 intervention/comparison) type 2 diabetes were from two parallel arm (lifestyle vs. comparison) randomized controlled trials. The associations of 91 established obesity-predisposing loci with weight loss across 4 years, and with weight regain across years-2-4 after a minimum of 3% weight loss, were tested. Each copy of the minor G allele of MTIF3 rs1885988... (More)
Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 intervention/comparison) type 2 diabetes were from two parallel arm (lifestyle vs. comparison) randomized controlled trials. The associations of 91 established obesity-predisposing loci with weight loss across 4 years, and with weight regain across years-2-4 after a minimum of 3% weight loss, were tested. Each copy of the minor G allele of MTIF3 rs1885988 was consistently associated with greater weight loss following lifestyle intervention over 4-years across DPP and LA. No such effect was observed across comparison arms, leading to a nominally significant SNP × treatment interaction (P=4.3×10(-3)). However, this effect was not significant at a study-wise significance level (Bonferroni threshold P<5·8×10(-4)). Most obesity-predisposing gene variants were not associated with weight loss or regain within the DPP and Look AHEAD trials, directly or via interactions with lifestyle. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
64
issue
12
pages
4312 - 4321
publisher
American Diabetes Association Inc.
external identifiers
  • pmid:26253612
  • wos:000365932900034
  • scopus:84962159225
ISSN
1939-327X
DOI
10.2337/db15-0441
language
English
LU publication?
yes
id
e98414a1-f3a4-4a4c-92f5-b575cfae97ae (old id 7844382)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26253612?dopt=Abstract
date added to LUP
2015-09-05 15:59:27
date last changed
2017-10-22 03:23:20
@article{e98414a1-f3a4-4a4c-92f5-b575cfae97ae,
  abstract     = {Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 intervention/comparison) type 2 diabetes were from two parallel arm (lifestyle vs. comparison) randomized controlled trials. The associations of 91 established obesity-predisposing loci with weight loss across 4 years, and with weight regain across years-2-4 after a minimum of 3% weight loss, were tested. Each copy of the minor G allele of MTIF3 rs1885988 was consistently associated with greater weight loss following lifestyle intervention over 4-years across DPP and LA. No such effect was observed across comparison arms, leading to a nominally significant SNP × treatment interaction (P=4.3×10(-3)). However, this effect was not significant at a study-wise significance level (Bonferroni threshold P&lt;5·8×10(-4)). Most obesity-predisposing gene variants were not associated with weight loss or regain within the DPP and Look AHEAD trials, directly or via interactions with lifestyle.},
  author       = {Papandonatos, George D and Pan, Qing and Pajewski, Nicholas M and Delahanty, Linda M and Peter, Inga and Erar, Bahar and Ahmad, Shafqat and Harden, Maegan and Chen, Ling and Fontanillas, Pierre and Wagenknecht, Lynne E and Kahn, Steven E and Wing, Rena R and Jablonski, Kathleen A and Huggins, Gordon S and Knowler, William C and Florez, Jose C and McCaffery, Jeanne M and Franks, Paul},
  issn         = {1939-327X},
  language     = {eng},
  number       = {12},
  pages        = {4312--4321},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Genetic predisposition to weight loss & regain with lifestyle intervention: analyses from the Diabetes Prevention Program & the Look AHEAD randomized controlled trials.},
  url          = {http://dx.doi.org/10.2337/db15-0441},
  volume       = {64},
  year         = {2015},
}