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Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

Sverrild, Asger; Bergqvist, Anders LU ; Baines, Katherine J; Porsbjerg, Celeste; Andersson, Cecilia LU ; Thomsen, Simon Francis; Hoffmann, Hans Jürgen; Gibson, Peter; Erjefält, Jonas LU and Backer, Vibeke (2016) In Clinical and Experimental Allergy 46(2). p.288-297
Abstract
Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Experimental Allergy
volume
46
issue
2
pages
288 - 297
publisher
Wiley-Blackwell
external identifiers
  • pmid:26252943
  • scopus:84955597145
  • wos:000370057800007
ISSN
1365-2222
DOI
10.1111/cea.12609
language
English
LU publication?
yes
id
899e97fe-150c-4355-a31f-361ce9eedbd2 (old id 7844404)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26252943?dopt=Abstract
date added to LUP
2015-09-05 16:02:17
date last changed
2017-08-06 04:47:27
@article{899e97fe-150c-4355-a31f-361ce9eedbd2,
  abstract     = {Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol.},
  author       = {Sverrild, Asger and Bergqvist, Anders and Baines, Katherine J and Porsbjerg, Celeste and Andersson, Cecilia and Thomsen, Simon Francis and Hoffmann, Hans Jürgen and Gibson, Peter and Erjefält, Jonas and Backer, Vibeke},
  issn         = {1365-2222},
  language     = {eng},
  number       = {2},
  pages        = {288--297},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical and Experimental Allergy},
  title        = {Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.},
  url          = {http://dx.doi.org/10.1111/cea.12609},
  volume       = {46},
  year         = {2016},
}