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Saliva S100B in professional sportsmen: High levels at resting conditions and increased after vigorous physical activity

Michetti, Fabrizio; Bruschettini, Matteo LU ; Frigiola, Alessandro; Abella, Raul; Giamberti, Alessandro; Marchese, Nora; Mangraviti, Salvatore; Melioli, Giovanni; Baldari, Amedeo and Bruschettini, Pierluigi, et al. (2011) In Clinical Biochemistry 44(2-3). p.245-247
Abstract
Background: Neurological dysfunction is a key medical concern in professional sportsmen (PSM). We investigated whether saliva S100B concentrations in PSM and healthy controls are modified before and after training. Methods: We conducted a case-control-study in 75 patients (25 PSM vs 50 controls) in which S100B saliva concentrations were expressed as absolute values and percentage of change (%) from samples drawn before (T0) and after (T1) training. Results: No differences (P>0.05) between groups were found regarding clinical, monitoring and laboratory parameters. S100B both in PSM and controls was higher at T1 when compared to TO (P<0.01). In PSM, S100B was higher than controls (P<0.001) at TO and T1. S100B% at T0-T1 was higher... (More)
Background: Neurological dysfunction is a key medical concern in professional sportsmen (PSM). We investigated whether saliva S100B concentrations in PSM and healthy controls are modified before and after training. Methods: We conducted a case-control-study in 75 patients (25 PSM vs 50 controls) in which S100B saliva concentrations were expressed as absolute values and percentage of change (%) from samples drawn before (T0) and after (T1) training. Results: No differences (P>0.05) between groups were found regarding clinical, monitoring and laboratory parameters. S100B both in PSM and controls was higher at T1 when compared to TO (P<0.01). In PSM, S100B was higher than controls (P<0.001) at TO and T1. S100B% at T0-T1 was higher (P<0.001) in PSM and in controls and between PSM and controls (P<0.001). Conclusions: Increased saliva S100B levels in PSM before and after training suggest a paracrine/autocrine protein's role connected to stressing activity, which becomes especially evident in PSMs. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. (Less)
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type
Contribution to journal
publication status
published
subject
keywords
Neurodegenerative disorders, Saliva, S100B protein, Sport
in
Clinical Biochemistry
volume
44
issue
2-3
pages
245 - 247
publisher
Elsevier
external identifiers
  • wos:000286959100018
  • scopus:79151480512
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2010.10.007
language
English
LU publication?
no
id
5a294f45-2647-4600-9fc1-df3bb44936cc (old id 7855486)
date added to LUP
2015-09-04 11:08:23
date last changed
2017-07-23 03:25:04
@article{5a294f45-2647-4600-9fc1-df3bb44936cc,
  abstract     = {Background: Neurological dysfunction is a key medical concern in professional sportsmen (PSM). We investigated whether saliva S100B concentrations in PSM and healthy controls are modified before and after training. Methods: We conducted a case-control-study in 75 patients (25 PSM vs 50 controls) in which S100B saliva concentrations were expressed as absolute values and percentage of change (%) from samples drawn before (T0) and after (T1) training. Results: No differences (P&gt;0.05) between groups were found regarding clinical, monitoring and laboratory parameters. S100B both in PSM and controls was higher at T1 when compared to TO (P&lt;0.01). In PSM, S100B was higher than controls (P&lt;0.001) at TO and T1. S100B% at T0-T1 was higher (P&lt;0.001) in PSM and in controls and between PSM and controls (P&lt;0.001). Conclusions: Increased saliva S100B levels in PSM before and after training suggest a paracrine/autocrine protein's role connected to stressing activity, which becomes especially evident in PSMs. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.},
  author       = {Michetti, Fabrizio and Bruschettini, Matteo and Frigiola, Alessandro and Abella, Raul and Giamberti, Alessandro and Marchese, Nora and Mangraviti, Salvatore and Melioli, Giovanni and Baldari, Amedeo and Bruschettini, Pierluigi and Gazzolo, Diego},
  issn         = {1873-2933},
  keyword      = {Neurodegenerative disorders,Saliva,S100B protein,Sport},
  language     = {eng},
  number       = {2-3},
  pages        = {245--247},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {Saliva S100B in professional sportsmen: High levels at resting conditions and increased after vigorous physical activity},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2010.10.007},
  volume       = {44},
  year         = {2011},
}