S100B protein in urine of preterm newborns with ominous outcome
Gazzolo, D ; Florio, P ; Ciotti, S ; Marinoni, E ; Di Iorio, R ; Bruschettini, Matteo LU
; Sacchi, R
; Serra, G
; Lituania, M
and Michetti, F
(2005)
In Pediatric Research
58(6).
p.1170-1174
- Abstract
- Prematurity is an important cause of perinatal death, and no reliable biochemical/biophysical markers exist to identify newborns with an increased mortality risk. We aimed to use S100B concentrations in urine as an early indicator of risk of neonatal death. We did a cross-sectional study using urine obtained from 165 preterm newborns, of whom I I suffered neonatal death within the first week, 121 displayed no overt neurologic syndrome, and 33 suffered neonatal hypoxia and intraventricular hemorrhage (IVH) but not ominous outcome. Urine S100B concentrations were determined at four time-points and corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Ultrasound imaging was... (More)
- Prematurity is an important cause of perinatal death, and no reliable biochemical/biophysical markers exist to identify newborns with an increased mortality risk. We aimed to use S100B concentrations in urine as an early indicator of risk of neonatal death. We did a cross-sectional study using urine obtained from 165 preterm newborns, of whom I I suffered neonatal death within the first week, 121 displayed no overt neurologic syndrome, and 33 suffered neonatal hypoxia and intraventricular hemorrhage (IVH) but not ominous outcome. Urine S100B concentrations were determined at four time-points and corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Ultrasound imaging was assessed within the first 72 h from birth. In infants that died within the first week, S100B levels in urine were already higher than controls at first urination and increased progressively between the 24 and 96-h time-points. Multiple logistic regression analysis showed a significant correlation between urine S100B protein concentrations and the occurrence of neonatal death. An S100B concentration cut-off of 12.93 MoM at first urination had a sensitivity of 100% and a specificity of 97.8% for predicting an ominous outcome. The positive predictive value was 78.6%, the negative predictive value was 100%. Measurement of urine S100B protein levels in preterm newborns could be useful to identify newborns at higher risk of neonatal death. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7856234
- author
- Gazzolo, D
; Florio, P
; Ciotti, S
; Marinoni, E
; Di Iorio, R
; Bruschettini, Matteo
LU
; Sacchi, R
; Serra, G
; Lituania, M
and Michetti, F
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pediatric Research
- volume
- 58
- issue
- 6
- pages
- 1170 - 1174
- publisher
- International Pediatric Foundation Inc.
- external identifiers
-
- wos:000233416500006
- scopus:33644801670
- ISSN
- 1530-0447
- DOI
- 10.1203/01.pdr.0000185131.22985.30
- language
- English
- LU publication?
- no
- id
- 0f2175f0-cab3-4cd4-9eef-1efdc4de28e4 (old id 7856234)
- date added to LUP
- 2016-04-01 11:52:35
- date last changed
- 2022-02-18 06:35:51
@article{0f2175f0-cab3-4cd4-9eef-1efdc4de28e4,
abstract = {{Prematurity is an important cause of perinatal death, and no reliable biochemical/biophysical markers exist to identify newborns with an increased mortality risk. We aimed to use S100B concentrations in urine as an early indicator of risk of neonatal death. We did a cross-sectional study using urine obtained from 165 preterm newborns, of whom I I suffered neonatal death within the first week, 121 displayed no overt neurologic syndrome, and 33 suffered neonatal hypoxia and intraventricular hemorrhage (IVH) but not ominous outcome. Urine S100B concentrations were determined at four time-points and corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Ultrasound imaging was assessed within the first 72 h from birth. In infants that died within the first week, S100B levels in urine were already higher than controls at first urination and increased progressively between the 24 and 96-h time-points. Multiple logistic regression analysis showed a significant correlation between urine S100B protein concentrations and the occurrence of neonatal death. An S100B concentration cut-off of 12.93 MoM at first urination had a sensitivity of 100% and a specificity of 97.8% for predicting an ominous outcome. The positive predictive value was 78.6%, the negative predictive value was 100%. Measurement of urine S100B protein levels in preterm newborns could be useful to identify newborns at higher risk of neonatal death.}},
author = {{Gazzolo, D and Florio, P and Ciotti, S and Marinoni, E and Di Iorio, R and Bruschettini, Matteo and Sacchi, R and Serra, G and Lituania, M and Michetti, F}},
issn = {{1530-0447}},
language = {{eng}},
number = {{6}},
pages = {{1170--1174}},
publisher = {{International Pediatric Foundation Inc.}},
series = {{Pediatric Research}},
title = {{S100B protein in urine of preterm newborns with ominous outcome}},
url = {{http://dx.doi.org/10.1203/01.pdr.0000185131.22985.30}},
doi = {{10.1203/01.pdr.0000185131.22985.30}},
volume = {{58}},
year = {{2005}},
}