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S100B protein in urine of preterm newborns with ominous outcome

Gazzolo, D; Florio, P; Ciotti, S; Marinoni, E; Di Iorio, R; Bruschettini, Matteo LU ; Sacchi, R; Serra, G; Lituania, M and Michetti, F (2005) In Pediatric Research 58(6). p.1170-1174
Abstract
Prematurity is an important cause of perinatal death, and no reliable biochemical/biophysical markers exist to identify newborns with an increased mortality risk. We aimed to use S100B concentrations in urine as an early indicator of risk of neonatal death. We did a cross-sectional study using urine obtained from 165 preterm newborns, of whom I I suffered neonatal death within the first week, 121 displayed no overt neurologic syndrome, and 33 suffered neonatal hypoxia and intraventricular hemorrhage (IVH) but not ominous outcome. Urine S100B concentrations were determined at four time-points and corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Ultrasound imaging was... (More)
Prematurity is an important cause of perinatal death, and no reliable biochemical/biophysical markers exist to identify newborns with an increased mortality risk. We aimed to use S100B concentrations in urine as an early indicator of risk of neonatal death. We did a cross-sectional study using urine obtained from 165 preterm newborns, of whom I I suffered neonatal death within the first week, 121 displayed no overt neurologic syndrome, and 33 suffered neonatal hypoxia and intraventricular hemorrhage (IVH) but not ominous outcome. Urine S100B concentrations were determined at four time-points and corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Ultrasound imaging was assessed within the first 72 h from birth. In infants that died within the first week, S100B levels in urine were already higher than controls at first urination and increased progressively between the 24 and 96-h time-points. Multiple logistic regression analysis showed a significant correlation between urine S100B protein concentrations and the occurrence of neonatal death. An S100B concentration cut-off of 12.93 MoM at first urination had a sensitivity of 100% and a specificity of 97.8% for predicting an ominous outcome. The positive predictive value was 78.6%, the negative predictive value was 100%. Measurement of urine S100B protein levels in preterm newborns could be useful to identify newborns at higher risk of neonatal death. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
58
issue
6
pages
1170 - 1174
publisher
International Pediatric Foundation Inc.
external identifiers
  • wos:000233416500006
  • scopus:33644801670
ISSN
1530-0447
DOI
10.1203/01.pdr.0000185131.22985.30
language
English
LU publication?
no
id
0f2175f0-cab3-4cd4-9eef-1efdc4de28e4 (old id 7856234)
date added to LUP
2015-09-07 12:16:56
date last changed
2017-01-01 04:37:32
@article{0f2175f0-cab3-4cd4-9eef-1efdc4de28e4,
  abstract     = {Prematurity is an important cause of perinatal death, and no reliable biochemical/biophysical markers exist to identify newborns with an increased mortality risk. We aimed to use S100B concentrations in urine as an early indicator of risk of neonatal death. We did a cross-sectional study using urine obtained from 165 preterm newborns, of whom I I suffered neonatal death within the first week, 121 displayed no overt neurologic syndrome, and 33 suffered neonatal hypoxia and intraventricular hemorrhage (IVH) but not ominous outcome. Urine S100B concentrations were determined at four time-points and corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Ultrasound imaging was assessed within the first 72 h from birth. In infants that died within the first week, S100B levels in urine were already higher than controls at first urination and increased progressively between the 24 and 96-h time-points. Multiple logistic regression analysis showed a significant correlation between urine S100B protein concentrations and the occurrence of neonatal death. An S100B concentration cut-off of 12.93 MoM at first urination had a sensitivity of 100% and a specificity of 97.8% for predicting an ominous outcome. The positive predictive value was 78.6%, the negative predictive value was 100%. Measurement of urine S100B protein levels in preterm newborns could be useful to identify newborns at higher risk of neonatal death.},
  author       = {Gazzolo, D and Florio, P and Ciotti, S and Marinoni, E and Di Iorio, R and Bruschettini, Matteo and Sacchi, R and Serra, G and Lituania, M and Michetti, F},
  issn         = {1530-0447},
  language     = {eng},
  number       = {6},
  pages        = {1170--1174},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {S100B protein in urine of preterm newborns with ominous outcome},
  url          = {http://dx.doi.org/10.1203/01.pdr.0000185131.22985.30},
  volume       = {58},
  year         = {2005},
}