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A single course of antenatal betamethasone reduces neurotrophic factor S100B concentration in the hippocampus and serum in the neonatal rat

Bruschettini, Matteo LU ; van den Hove, DLA; Gazzolo, D; Bruschettini, P; Blanco, CE and Steinbusch, HWM (2005) In Developmental Brain Research 159(2). p.113-118
Abstract
The effects of a single course of antenatal betamethasone on S100B protein concentration were investigated in Fisher 344 rats. On day 20 of gestation, pregnant rats were injected twice 8 h apart with either (1) 170 mu g kg(-1) body weight betamethasone ("clinically-equivalent dose", equivalent to 12 mg twice, 24 h apart in humans), (2) half of this dose (equivalent to 6 mg) or (3) vehicle. We report reference values for S100B protein in the serum and different brain regions in both genders at 1, 2, and 21 days after birth. Interestingly, S100B concentration showed a time-dependent and brain region-specific pattern of expression. At P1, S100B was higher in the serum of males compared to females. In addition, we show that both doses of... (More)
The effects of a single course of antenatal betamethasone on S100B protein concentration were investigated in Fisher 344 rats. On day 20 of gestation, pregnant rats were injected twice 8 h apart with either (1) 170 mu g kg(-1) body weight betamethasone ("clinically-equivalent dose", equivalent to 12 mg twice, 24 h apart in humans), (2) half of this dose (equivalent to 6 mg) or (3) vehicle. We report reference values for S100B protein in the serum and different brain regions in both genders at 1, 2, and 21 days after birth. Interestingly, S100B concentration showed a time-dependent and brain region-specific pattern of expression. At P1, S100B was higher in the serum of males compared to females. In addition, we show that both doses of betamethasone decreased S100B concentration in the serum of males at P1, whereas in the hippocampus, it was reduced by the clinically-equivalent dose only. This suggests that lowering the dose of antenatal betamethasone may be less detrimental for brain maturation and therefore we reiterate the need for clinical trials with a low dose regimen. (c) 2005 Elsevier B.V. All rights reserved. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glucocorticoid, corticosteroid, prenatal, steroid, side-effect, brain development
in
Developmental Brain Research
volume
159
issue
2
pages
113 - 118
publisher
Elsevier
external identifiers
  • wos:000232524900004
  • scopus:25144514584
ISSN
0165-3806
DOI
10.1016/j.devbrainres.2005.07.003
language
English
LU publication?
no
id
b7a9ea5e-2713-4a4e-b80c-6490b66994d0 (old id 7856253)
date added to LUP
2015-09-07 12:14:51
date last changed
2017-01-01 07:24:55
@article{b7a9ea5e-2713-4a4e-b80c-6490b66994d0,
  abstract     = {The effects of a single course of antenatal betamethasone on S100B protein concentration were investigated in Fisher 344 rats. On day 20 of gestation, pregnant rats were injected twice 8 h apart with either (1) 170 mu g kg(-1) body weight betamethasone ("clinically-equivalent dose", equivalent to 12 mg twice, 24 h apart in humans), (2) half of this dose (equivalent to 6 mg) or (3) vehicle. We report reference values for S100B protein in the serum and different brain regions in both genders at 1, 2, and 21 days after birth. Interestingly, S100B concentration showed a time-dependent and brain region-specific pattern of expression. At P1, S100B was higher in the serum of males compared to females. In addition, we show that both doses of betamethasone decreased S100B concentration in the serum of males at P1, whereas in the hippocampus, it was reduced by the clinically-equivalent dose only. This suggests that lowering the dose of antenatal betamethasone may be less detrimental for brain maturation and therefore we reiterate the need for clinical trials with a low dose regimen. (c) 2005 Elsevier B.V. All rights reserved.},
  author       = {Bruschettini, Matteo and van den Hove, DLA and Gazzolo, D and Bruschettini, P and Blanco, CE and Steinbusch, HWM},
  issn         = {0165-3806},
  keyword      = {glucocorticoid,corticosteroid,prenatal,steroid,side-effect,brain development},
  language     = {eng},
  number       = {2},
  pages        = {113--118},
  publisher    = {Elsevier},
  series       = {Developmental Brain Research},
  title        = {A single course of antenatal betamethasone reduces neurotrophic factor S100B concentration in the hippocampus and serum in the neonatal rat},
  url          = {http://dx.doi.org/10.1016/j.devbrainres.2005.07.003},
  volume       = {159},
  year         = {2005},
}