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S100B protein levels in saliva: correlation with gestational age in normal term and preterm newborns

Gazzolo, D; Lituania, M; Bruschettini, Matteo LU ; Ciotti, S; Sacchi, R; Serra, G; Calevo, MG; Corvino, V; Buonocore, G and Michetti, F (2005) In Clinical Biochemistry 38(3). p.229-233
Abstract
Objectives: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. Design and methods: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns. Results: S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was... (More)
Objectives: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. Design and methods: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns. Results: S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was correlated with gestational age (r = -0.69; P < 0.001). Conclusions: The present study offers data consistent with the putative neurotrophic role of S100B and suggests the usefulness of saliva in the clinical monitoring of S100B levels. (C) 2005 The Canadian Society of Clinical Chemists. All rights reserved. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
S100B protein, newborn, saliva, cytokine, neurotrophic factor, central, nervous system
in
Clinical Biochemistry
volume
38
issue
3
pages
229 - 233
publisher
Elsevier
external identifiers
  • wos:000227206700004
  • scopus:20844431858
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2004.12.006
language
English
LU publication?
no
id
90674a4e-c358-4a54-afb2-af1bd0d0c549 (old id 7856278)
date added to LUP
2015-09-07 11:10:51
date last changed
2017-10-22 03:45:59
@article{90674a4e-c358-4a54-afb2-af1bd0d0c549,
  abstract     = {Objectives: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. Design and methods: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of the protein was established in 216 preterm and term newborns. Results: S100B levels were significantly higher in saliva taken from the preterm group, and the highest S100B levels were found in newborns who were delivered in the earlier weeks of gestation, exhibiting a progressive decrease nearer to term. S100B concentration in saliva was correlated with gestational age (r = -0.69; P &lt; 0.001). Conclusions: The present study offers data consistent with the putative neurotrophic role of S100B and suggests the usefulness of saliva in the clinical monitoring of S100B levels. (C) 2005 The Canadian Society of Clinical Chemists. All rights reserved.},
  author       = {Gazzolo, D and Lituania, M and Bruschettini, Matteo and Ciotti, S and Sacchi, R and Serra, G and Calevo, MG and Corvino, V and Buonocore, G and Michetti, F},
  issn         = {1873-2933},
  keyword      = {S100B protein,newborn,saliva,cytokine,neurotrophic factor,central,nervous system},
  language     = {eng},
  number       = {3},
  pages        = {229--233},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {S100B protein levels in saliva: correlation with gestational age in normal term and preterm newborns},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2004.12.006},
  volume       = {38},
  year         = {2005},
}