Amniotic fluid S100B protein in mid-gestation and intrauterine fetal death
(2004) In The Lancet 364(9430). p.270-272- Abstract
- Fetal death in the mid-trimester of pregnancy is unexplained and no reliable markers are available to identify at-risk women. We aimed to assess use of a fetoprotein and S100B concentrations in amniotic fluid as markers. We did a case-control study in 758 healthy women undergoing amniocentesis at mid-gestation, of whom 12 had a spontaneous intrauterine fetal death before 28 weeks, and 746 matched controls. Concentrations were corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Concentrations of S100B, but not alpha fetoprotein, were significantly higher (p<0.0001) in women who later had spontaneous fetal death (median 4.431 MoM [95%CI 3.605-6.197]) than in controls... (More)
- Fetal death in the mid-trimester of pregnancy is unexplained and no reliable markers are available to identify at-risk women. We aimed to assess use of a fetoprotein and S100B concentrations in amniotic fluid as markers. We did a case-control study in 758 healthy women undergoing amniocentesis at mid-gestation, of whom 12 had a spontaneous intrauterine fetal death before 28 weeks, and 746 matched controls. Concentrations were corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Concentrations of S100B, but not alpha fetoprotein, were significantly higher (p<0.0001) in women who later had spontaneous fetal death (median 4.431 MoM [95%CI 3.605-6.197]) than in controls (1.000 MoM [1.062-1.121]). Sensitivity, specificity, and positive and negative predictive values of S100B as a diagnostic test were 100%, suggesting that measurement of this protein at amniocentesis could be useful to identify at-risk women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7856332
- author
- Florio, P ; Michetti, F ; Bruschettini, Matteo LU ; Lituania, M ; Bruschettini, P ; Severi, FM ; Petraglia, F and Gazzolo, D
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Lancet
- volume
- 364
- issue
- 9430
- pages
- 270 - 272
- publisher
- Elsevier
- external identifiers
-
- wos:000222784900030
- scopus:3242685259
- ISSN
- 1474-547X
- DOI
- 10.1016/S0140-6736(04)16677-4
- language
- English
- LU publication?
- no
- id
- 31dad38e-e504-4cce-b611-98e8298ee6cc (old id 7856332)
- date added to LUP
- 2016-04-01 11:45:22
- date last changed
- 2022-03-13 00:12:17
@article{31dad38e-e504-4cce-b611-98e8298ee6cc, abstract = {{Fetal death in the mid-trimester of pregnancy is unexplained and no reliable markers are available to identify at-risk women. We aimed to assess use of a fetoprotein and S100B concentrations in amniotic fluid as markers. We did a case-control study in 758 healthy women undergoing amniocentesis at mid-gestation, of whom 12 had a spontaneous intrauterine fetal death before 28 weeks, and 746 matched controls. Concentrations were corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Concentrations of S100B, but not alpha fetoprotein, were significantly higher (p<0.0001) in women who later had spontaneous fetal death (median 4.431 MoM [95%CI 3.605-6.197]) than in controls (1.000 MoM [1.062-1.121]). Sensitivity, specificity, and positive and negative predictive values of S100B as a diagnostic test were 100%, suggesting that measurement of this protein at amniocentesis could be useful to identify at-risk women.}}, author = {{Florio, P and Michetti, F and Bruschettini, Matteo and Lituania, M and Bruschettini, P and Severi, FM and Petraglia, F and Gazzolo, D}}, issn = {{1474-547X}}, language = {{eng}}, number = {{9430}}, pages = {{270--272}}, publisher = {{Elsevier}}, series = {{The Lancet}}, title = {{Amniotic fluid S100B protein in mid-gestation and intrauterine fetal death}}, url = {{http://dx.doi.org/10.1016/S0140-6736(04)16677-4}}, doi = {{10.1016/S0140-6736(04)16677-4}}, volume = {{364}}, year = {{2004}}, }