Advanced

Amniotic fluid S100B protein in mid-gestation and intrauterine fetal death

Florio, P; Michetti, F; Bruschettini, Matteo LU ; Lituania, M; Bruschettini, P; Severi, FM; Petraglia, F and Gazzolo, D (2004) In The Lancet 364(9430). p.270-272
Abstract
Fetal death in the mid-trimester of pregnancy is unexplained and no reliable markers are available to identify at-risk women. We aimed to assess use of a fetoprotein and S100B concentrations in amniotic fluid as markers. We did a case-control study in 758 healthy women undergoing amniocentesis at mid-gestation, of whom 12 had a spontaneous intrauterine fetal death before 28 weeks, and 746 matched controls. Concentrations were corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Concentrations of S100B, but not alpha fetoprotein, were significantly higher (p<0.0001) in women who later had spontaneous fetal death (median 4.431 MoM [95%CI 3.605-6.197]) than in controls... (More)
Fetal death in the mid-trimester of pregnancy is unexplained and no reliable markers are available to identify at-risk women. We aimed to assess use of a fetoprotein and S100B concentrations in amniotic fluid as markers. We did a case-control study in 758 healthy women undergoing amniocentesis at mid-gestation, of whom 12 had a spontaneous intrauterine fetal death before 28 weeks, and 746 matched controls. Concentrations were corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Concentrations of S100B, but not alpha fetoprotein, were significantly higher (p<0.0001) in women who later had spontaneous fetal death (median 4.431 MoM [95%CI 3.605-6.197]) than in controls (1.000 MoM [1.062-1.121]). Sensitivity, specificity, and positive and negative predictive values of S100B as a diagnostic test were 100%, suggesting that measurement of this protein at amniocentesis could be useful to identify at-risk women. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
364
issue
9430
pages
270 - 272
publisher
Elsevier Limited
external identifiers
  • wos:000222784900030
  • scopus:3242685259
ISSN
1474-547X
DOI
10.1016/S0140-6736(04)16677-4
language
English
LU publication?
no
id
31dad38e-e504-4cce-b611-98e8298ee6cc (old id 7856332)
date added to LUP
2015-09-07 10:58:26
date last changed
2017-10-22 03:37:14
@article{31dad38e-e504-4cce-b611-98e8298ee6cc,
  abstract     = {Fetal death in the mid-trimester of pregnancy is unexplained and no reliable markers are available to identify at-risk women. We aimed to assess use of a fetoprotein and S100B concentrations in amniotic fluid as markers. We did a case-control study in 758 healthy women undergoing amniocentesis at mid-gestation, of whom 12 had a spontaneous intrauterine fetal death before 28 weeks, and 746 matched controls. Concentrations were corrected for gestational age by conversion to multiples of median (MoM) of healthy controls of the same gestational age. Concentrations of S100B, but not alpha fetoprotein, were significantly higher (p&lt;0.0001) in women who later had spontaneous fetal death (median 4.431 MoM [95%CI 3.605-6.197]) than in controls (1.000 MoM [1.062-1.121]). Sensitivity, specificity, and positive and negative predictive values of S100B as a diagnostic test were 100%, suggesting that measurement of this protein at amniocentesis could be useful to identify at-risk women.},
  author       = {Florio, P and Michetti, F and Bruschettini, Matteo and Lituania, M and Bruschettini, P and Severi, FM and Petraglia, F and Gazzolo, D},
  issn         = {1474-547X},
  language     = {eng},
  number       = {9430},
  pages        = {270--272},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {Amniotic fluid S100B protein in mid-gestation and intrauterine fetal death},
  url          = {http://dx.doi.org/10.1016/S0140-6736(04)16677-4},
  volume       = {364},
  year         = {2004},
}