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Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks

Gazzolo, D; Bruschettini, Matteo LU ; Lituania, M; Serra, G; Santini, P and Michetti, F (2004) In Clinical Nutrition 23(1). p.23-26
Abstract
Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae. Methods: Samples for S100B measurements were collected from human cotostrum (on day 1 after birth), from transition milk (on post-delivery days 7 and 14) and from mature milk (on day 30 after delivery) in 14 healthy women and from 14 milk-formulae. The S100B protein levels were measured using a commercially available specific... (More)
Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae. Methods: Samples for S100B measurements were collected from human cotostrum (on day 1 after birth), from transition milk (on post-delivery days 7 and 14) and from mature milk (on day 30 after delivery) in 14 healthy women and from 14 milk-formulae. The S100B protein levels were measured using a commercially available specific immunoluminometric assay. Results: Mean S100B protein levels were significantly higher in mature human milk (117.9+/-36.7 mug/l) than in transition milk at 14 days (106.7+/-38.1 mug/l) and at 7 days (92.7+/-37.8 mug/l), cotostrum (74.6+/-37.6 mug/l) or milk-formulae (24.8+/-19.5 mug/l) (P<0.001, for all). A correlation between human milk S100B Levels and the gestational age at which samples were obtained was also found (r=0.39; P<0.01). Conclusions: These findings, possibly related to S100B's neurotrophic role, offers useful information to the investigation of the role of S100B protein in brain maturation. (C) 2003 Elsevier Ltd. ALL rights reserved. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
milk-formulae, colostrum, human milk, brain maturation, newborn, S100B protein
in
Clinical Nutrition
volume
23
issue
1
pages
23 - 26
publisher
Elsevier
external identifiers
  • wos:000189319400004
  • scopus:1242319552
ISSN
1532-1983
DOI
10.1016/S0261-5614(03)00084-0
language
English
LU publication?
no
id
589fdaac-9743-4b18-a5a1-7849593755de (old id 7856363)
date added to LUP
2015-09-07 10:56:46
date last changed
2017-01-01 07:10:44
@article{589fdaac-9743-4b18-a5a1-7849593755de,
  abstract     = {Background &amp; Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae. Methods: Samples for S100B measurements were collected from human cotostrum (on day 1 after birth), from transition milk (on post-delivery days 7 and 14) and from mature milk (on day 30 after delivery) in 14 healthy women and from 14 milk-formulae. The S100B protein levels were measured using a commercially available specific immunoluminometric assay. Results: Mean S100B protein levels were significantly higher in mature human milk (117.9+/-36.7 mug/l) than in transition milk at 14 days (106.7+/-38.1 mug/l) and at 7 days (92.7+/-37.8 mug/l), cotostrum (74.6+/-37.6 mug/l) or milk-formulae (24.8+/-19.5 mug/l) (P&lt;0.001, for all). A correlation between human milk S100B Levels and the gestational age at which samples were obtained was also found (r=0.39; P&lt;0.01). Conclusions: These findings, possibly related to S100B's neurotrophic role, offers useful information to the investigation of the role of S100B protein in brain maturation. (C) 2003 Elsevier Ltd. ALL rights reserved.},
  author       = {Gazzolo, D and Bruschettini, Matteo and Lituania, M and Serra, G and Santini, P and Michetti, F},
  issn         = {1532-1983},
  keyword      = {milk-formulae,colostrum,human milk,brain maturation,newborn,S100B protein},
  language     = {eng},
  number       = {1},
  pages        = {23--26},
  publisher    = {Elsevier},
  series       = {Clinical Nutrition},
  title        = {Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks},
  url          = {http://dx.doi.org/10.1016/S0261-5614(03)00084-0},
  volume       = {23},
  year         = {2004},
}