Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks
Gazzolo, D ; Bruschettini, Matteo LU
; Lituania, M
; Serra, G
; Santini, P
and Michetti, F
(2004)
In Clinical Nutrition
23(1).
p.23-26
- Abstract
- Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae. Methods: Samples for S100B measurements were collected from human cotostrum (on day 1 after birth), from transition milk (on post-delivery days 7 and 14) and from mature milk (on day 30 after delivery) in 14 healthy women and from 14 milk-formulae. The S100B protein levels were measured using a commercially available specific... (More)
- Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae. Methods: Samples for S100B measurements were collected from human cotostrum (on day 1 after birth), from transition milk (on post-delivery days 7 and 14) and from mature milk (on day 30 after delivery) in 14 healthy women and from 14 milk-formulae. The S100B protein levels were measured using a commercially available specific immunoluminometric assay. Results: Mean S100B protein levels were significantly higher in mature human milk (117.9+/-36.7 mug/l) than in transition milk at 14 days (106.7+/-38.1 mug/l) and at 7 days (92.7+/-37.8 mug/l), cotostrum (74.6+/-37.6 mug/l) or milk-formulae (24.8+/-19.5 mug/l) (P<0.001, for all). A correlation between human milk S100B Levels and the gestational age at which samples were obtained was also found (r=0.39; P<0.01). Conclusions: These findings, possibly related to S100B's neurotrophic role, offers useful information to the investigation of the role of S100B protein in brain maturation. (C) 2003 Elsevier Ltd. ALL rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7856363
- author
- Gazzolo, D
; Bruschettini, Matteo
LU
; Lituania, M
; Serra, G
; Santini, P
and Michetti, F
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- milk-formulae, colostrum, human milk, brain maturation, newborn, S100B protein
- in
- Clinical Nutrition
- volume
- 23
- issue
- 1
- pages
- 23 - 26
- publisher
- Elsevier
- external identifiers
-
- wos:000189319400004
- scopus:1242319552
- ISSN
- 1532-1983
- DOI
- 10.1016/S0261-5614(03)00084-0
- language
- English
- LU publication?
- no
- id
- 589fdaac-9743-4b18-a5a1-7849593755de (old id 7856363)
- date added to LUP
- 2016-04-01 16:38:20
- date last changed
- 2022-01-28 21:06:44
@article{589fdaac-9743-4b18-a5a1-7849593755de,
abstract = {{Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae. Methods: Samples for S100B measurements were collected from human cotostrum (on day 1 after birth), from transition milk (on post-delivery days 7 and 14) and from mature milk (on day 30 after delivery) in 14 healthy women and from 14 milk-formulae. The S100B protein levels were measured using a commercially available specific immunoluminometric assay. Results: Mean S100B protein levels were significantly higher in mature human milk (117.9+/-36.7 mug/l) than in transition milk at 14 days (106.7+/-38.1 mug/l) and at 7 days (92.7+/-37.8 mug/l), cotostrum (74.6+/-37.6 mug/l) or milk-formulae (24.8+/-19.5 mug/l) (P<0.001, for all). A correlation between human milk S100B Levels and the gestational age at which samples were obtained was also found (r=0.39; P<0.01). Conclusions: These findings, possibly related to S100B's neurotrophic role, offers useful information to the investigation of the role of S100B protein in brain maturation. (C) 2003 Elsevier Ltd. ALL rights reserved.}},
author = {{Gazzolo, D and Bruschettini, Matteo and Lituania, M and Serra, G and Santini, P and Michetti, F}},
issn = {{1532-1983}},
keywords = {{milk-formulae; colostrum; human milk; brain maturation; newborn; S100B protein}},
language = {{eng}},
number = {{1}},
pages = {{23--26}},
publisher = {{Elsevier}},
series = {{Clinical Nutrition}},
title = {{Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks}},
url = {{http://dx.doi.org/10.1016/S0261-5614(03)00084-0}},
doi = {{10.1016/S0261-5614(03)00084-0}},
volume = {{23}},
year = {{2004}},
}