Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses

Gazzolo, D ; Bruschettini, Matteo LU orcid ; Corvino, V ; Lituania, M ; Sarli, R ; Bruschettini, P and Michetti, F (2003) In Clinica Chimica Acta 330(1-2). p.131-133
Abstract
Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p < 0.05). Conclusion: The... (More)
Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p < 0.05). Conclusion: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool. (C) 2003 Elsevier Science B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
trisomy-21, ammotic fluid, brain maturation, foetus, S100B protein
in
Clinica Chimica Acta
volume
330
issue
1-2
pages
131 - 133
publisher
Elsevier
external identifiers
  • wos:000181953800008
  • scopus:0037375570
ISSN
0009-8981
DOI
10.1016/S0009-8981(03)00010-X
language
English
LU publication?
no
id
04134fda-9211-4356-979a-a7b3014bfa66 (old id 7856420)
date added to LUP
2016-04-01 11:59:40
date last changed
2022-01-26 21:17:18
@article{04134fda-9211-4356-979a-a7b3014bfa66,
  abstract     = {{Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p &lt; 0.05). Conclusion: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool. (C) 2003 Elsevier Science B.V. All rights reserved.}},
  author       = {{Gazzolo, D and Bruschettini, Matteo and Corvino, V and Lituania, M and Sarli, R and Bruschettini, P and Michetti, F}},
  issn         = {{0009-8981}},
  keywords     = {{trisomy-21; ammotic fluid; brain maturation; foetus; S100B protein}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{131--133}},
  publisher    = {{Elsevier}},
  series       = {{Clinica Chimica Acta}},
  title        = {{Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses}},
  url          = {{http://dx.doi.org/10.1016/S0009-8981(03)00010-X}},
  doi          = {{10.1016/S0009-8981(03)00010-X}},
  volume       = {{330}},
  year         = {{2003}},
}