Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses
(2003) In Clinica Chimica Acta 330(1-2). p.131-133- Abstract
- Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p < 0.05). Conclusion: The... (More)
- Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p < 0.05). Conclusion: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool. (C) 2003 Elsevier Science B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7856420
- author
- Gazzolo, D ; Bruschettini, Matteo LU ; Corvino, V ; Lituania, M ; Sarli, R ; Bruschettini, P and Michetti, F
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- trisomy-21, ammotic fluid, brain maturation, foetus, S100B protein
- in
- Clinica Chimica Acta
- volume
- 330
- issue
- 1-2
- pages
- 131 - 133
- publisher
- Elsevier
- external identifiers
-
- wos:000181953800008
- scopus:0037375570
- ISSN
- 0009-8981
- DOI
- 10.1016/S0009-8981(03)00010-X
- language
- English
- LU publication?
- no
- id
- 04134fda-9211-4356-979a-a7b3014bfa66 (old id 7856420)
- date added to LUP
- 2016-04-01 11:59:40
- date last changed
- 2022-01-26 21:17:18
@article{04134fda-9211-4356-979a-a7b3014bfa66, abstract = {{Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p < 0.05). Conclusion: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool. (C) 2003 Elsevier Science B.V. All rights reserved.}}, author = {{Gazzolo, D and Bruschettini, Matteo and Corvino, V and Lituania, M and Sarli, R and Bruschettini, P and Michetti, F}}, issn = {{0009-8981}}, keywords = {{trisomy-21; ammotic fluid; brain maturation; foetus; S100B protein}}, language = {{eng}}, number = {{1-2}}, pages = {{131--133}}, publisher = {{Elsevier}}, series = {{Clinica Chimica Acta}}, title = {{Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses}}, url = {{http://dx.doi.org/10.1016/S0009-8981(03)00010-X}}, doi = {{10.1016/S0009-8981(03)00010-X}}, volume = {{330}}, year = {{2003}}, }