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Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses

Gazzolo, D; Bruschettini, Matteo LU ; Corvino, V; Lituania, M; Sarli, R; Bruschettini, P and Michetti, F (2003) In Clinica Chimica Acta 330(1-2). p.131-133
Abstract
Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p < 0.05). Conclusion: The... (More)
Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p < 0.05). Conclusion: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool. (C) 2003 Elsevier Science B.V. All rights reserved. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
trisomy-21, ammotic fluid, brain maturation, foetus, S100B protein
in
Clinica Chimica Acta
volume
330
issue
1-2
pages
131 - 133
publisher
Elsevier
external identifiers
  • wos:000181953800008
  • scopus:0037375570
ISSN
0009-8981
DOI
10.1016/S0009-8981(03)00010-X
language
English
LU publication?
no
id
04134fda-9211-4356-979a-a7b3014bfa66 (old id 7856420)
date added to LUP
2015-09-07 10:43:26
date last changed
2018-05-29 10:59:33
@article{04134fda-9211-4356-979a-a7b3014bfa66,
  abstract     = {Background: The human chromosome 21 has been shown to contain the gene for the subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S 10013 in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83 +/- 0.21 mug/l) than in controls (0.51 +/- 0.22 mug/l) (p &lt; 0.05). Conclusion: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool. (C) 2003 Elsevier Science B.V. All rights reserved.},
  author       = {Gazzolo, D and Bruschettini, Matteo and Corvino, V and Lituania, M and Sarli, R and Bruschettini, P and Michetti, F},
  issn         = {0009-8981},
  keyword      = {trisomy-21,ammotic fluid,brain maturation,foetus,S100B protein},
  language     = {eng},
  number       = {1-2},
  pages        = {131--133},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses},
  url          = {http://dx.doi.org/10.1016/S0009-8981(03)00010-X},
  volume       = {330},
  year         = {2003},
}