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The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Örbom, Anders LU ; Eriksson, Sophie LU ; Elgström, Erika LU ; Ohlsson, Tomas G LU ; Nilsson, Rune LU ; Tennvall, Jan LU and Strand, Sven-Erik LU (2013) In Journal of Nuclear Medicine 54(8). p.1404-1410
Abstract
The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
54
issue
8
pages
1404 - 1410
publisher
Society of Nuclear Medicine
external identifiers
  • wos:000322692400054
  • pmid:23804328
  • scopus:84876839931
  • pmid:23804328
ISSN
0161-5505
DOI
10.2967/jnumed.112.117028
language
English
LU publication?
yes
id
78f71df6-aba7-4a38-9f7a-75ba155939b9 (old id 3912939)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23804328?dopt=Abstract
date added to LUP
2016-04-01 11:06:46
date last changed
2020-01-12 07:12:00
@article{78f71df6-aba7-4a38-9f7a-75ba155939b9,
  abstract     = {The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.},
  author       = {Örbom, Anders and Eriksson, Sophie and Elgström, Erika and Ohlsson, Tomas G and Nilsson, Rune and Tennvall, Jan and Strand, Sven-Erik},
  issn         = {0161-5505},
  language     = {eng},
  number       = {8},
  pages        = {1404--1410},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.},
  url          = {https://lup.lub.lu.se/search/ws/files/2390625/4144958.pdf},
  doi          = {10.2967/jnumed.112.117028},
  volume       = {54},
  year         = {2013},
}