Obesity and the risk of cardiometabolic diseases
(2023) In Nature Reviews Cardiology 20(7). p.475-494- Abstract
The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardiometabolic consequences and discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases. We also examine the role of potential moderators of this association, with evidence for and against the so-called ‘metabolically healthy obesity phenotype’, the ‘fatness but fitness’ paradox or the... (More)
The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardiometabolic consequences and discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases. We also examine the role of potential moderators of this association, with evidence for and against the so-called ‘metabolically healthy obesity phenotype’, the ‘fatness but fitness’ paradox or the ‘obesity paradox’. Although maintenance of optimal cardiometabolic status should be a primary goal in individuals with obesity, losing body weight and, particularly, excess visceral adiposity seems to be necessary to minimize the risk of cardiometabolic diseases.
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- author
- Valenzuela, Pedro L. ; Carrera-Bastos, Pedro LU ; Castillo-García, Adrián ; Lieberman, Daniel E. ; Santos-Lozano, Alejandro and Lucia, Alejandro
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews Cardiology
- volume
- 20
- issue
- 7
- pages
- 475 - 494
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:36927772
- scopus:85150045727
- ISSN
- 1759-5002
- DOI
- 10.1038/s41569-023-00847-5
- language
- English
- LU publication?
- yes
- id
- 7904d1c8-1932-4566-84f2-f754104334a2
- date added to LUP
- 2023-04-04 15:10:03
- date last changed
- 2024-07-12 19:57:47
@article{7904d1c8-1932-4566-84f2-f754104334a2,
abstract = {{<p>The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardiometabolic consequences and discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases. We also examine the role of potential moderators of this association, with evidence for and against the so-called ‘metabolically healthy obesity phenotype’, the ‘fatness but fitness’ paradox or the ‘obesity paradox’. Although maintenance of optimal cardiometabolic status should be a primary goal in individuals with obesity, losing body weight and, particularly, excess visceral adiposity seems to be necessary to minimize the risk of cardiometabolic diseases.</p>}},
author = {{Valenzuela, Pedro L. and Carrera-Bastos, Pedro and Castillo-García, Adrián and Lieberman, Daniel E. and Santos-Lozano, Alejandro and Lucia, Alejandro}},
issn = {{1759-5002}},
language = {{eng}},
number = {{7}},
pages = {{475--494}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews Cardiology}},
title = {{Obesity and the risk of cardiometabolic diseases}},
url = {{http://dx.doi.org/10.1038/s41569-023-00847-5}},
doi = {{10.1038/s41569-023-00847-5}},
volume = {{20}},
year = {{2023}},
}