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A prospective, multicenter validation study of a prognostic index composed of S-phase fraction, progesterone receptor status, and tumour size predicts survival in node-negative breast cancer patients: NNBC, the node-negative breast cancer trial.

Klintman, Marie LU ; Nilsson, F ; Bendahl, P-O ; Fernö, Mårten LU ; Liljegren, G ; Emdin, S and Malmström, Per LU (2013) In Annals of Oncology 24(9). p.2284-2291
Abstract
BACKGROUND: In a retrospective study on node-negative breast cancer, a prognostic index consisting of a proliferation factor, S-phase fraction (SPF), progesterone receptor status (PR), and tumour size identified one-third of patients as high risk, with a sixfold increased risk of breast cancer death. This prospective multicenter cohort study was set up to validate the index. PATIENTS AND METHODS: In 576 T1-2N0 patients <60 years, prospective analyses of PR and SPF were carried out. High risk was defined as ≥2 of the following: size >20 mm, PR-negativity, and high SPF (in the absence of SPF, Bloom-Richardson grade 3). Median follow-up was 17.8 years. RESULTS: Thirty-one percent were high risk. In univariate analysis, the index was... (More)
BACKGROUND: In a retrospective study on node-negative breast cancer, a prognostic index consisting of a proliferation factor, S-phase fraction (SPF), progesterone receptor status (PR), and tumour size identified one-third of patients as high risk, with a sixfold increased risk of breast cancer death. This prospective multicenter cohort study was set up to validate the index. PATIENTS AND METHODS: In 576 T1-2N0 patients <60 years, prospective analyses of PR and SPF were carried out. High risk was defined as ≥2 of the following: size >20 mm, PR-negativity, and high SPF (in the absence of SPF, Bloom-Richardson grade 3). Median follow-up was 17.8 years. RESULTS: Thirty-one percent were high risk. In univariate analysis, the index was prognostic for breast cancer-specific survival after 5 years [hazard ratio (HR) = 4.7, 95% confidence interval (95% CI) 2.5-8.9], 10 years (HR = 2.2, 95% CI 1.5-3.3), and 15 years (HR = 1.7, 95% CI 1.2-2.5), and remained significant after adjustment for adjuvant medical treatment and age. In the 37% of patients with no risk factors, only one patient died of breast cancer the first 5 years. CONCLUSIONS: This prospective study validates a prognostic index consisting of a proliferation factor, PR-status, and tumour size. The index may be helpful for prognostic considerations and for selection of patients in need of adjuvant therapy. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Oncology
volume
24
issue
9
pages
2284 - 2291
publisher
Oxford University Press
external identifiers
  • wos:000323963100012
  • pmid:23704202
  • scopus:84883346419
  • pmid:23704202
ISSN
1569-8041
DOI
10.1093/annonc/mdt186
language
English
LU publication?
yes
id
7916d799-6e89-45b9-bdbb-022bcc3ce7eb (old id 3804180)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23704202?dopt=Abstract
date added to LUP
2016-04-01 10:43:22
date last changed
2022-04-04 20:44:32
@article{7916d799-6e89-45b9-bdbb-022bcc3ce7eb,
  abstract     = {{BACKGROUND: In a retrospective study on node-negative breast cancer, a prognostic index consisting of a proliferation factor, S-phase fraction (SPF), progesterone receptor status (PR), and tumour size identified one-third of patients as high risk, with a sixfold increased risk of breast cancer death. This prospective multicenter cohort study was set up to validate the index. PATIENTS AND METHODS: In 576 T1-2N0 patients &lt;60 years, prospective analyses of PR and SPF were carried out. High risk was defined as ≥2 of the following: size &gt;20 mm, PR-negativity, and high SPF (in the absence of SPF, Bloom-Richardson grade 3). Median follow-up was 17.8 years. RESULTS: Thirty-one percent were high risk. In univariate analysis, the index was prognostic for breast cancer-specific survival after 5 years [hazard ratio (HR) = 4.7, 95% confidence interval (95% CI) 2.5-8.9], 10 years (HR = 2.2, 95% CI 1.5-3.3), and 15 years (HR = 1.7, 95% CI 1.2-2.5), and remained significant after adjustment for adjuvant medical treatment and age. In the 37% of patients with no risk factors, only one patient died of breast cancer the first 5 years. CONCLUSIONS: This prospective study validates a prognostic index consisting of a proliferation factor, PR-status, and tumour size. The index may be helpful for prognostic considerations and for selection of patients in need of adjuvant therapy.}},
  author       = {{Klintman, Marie and Nilsson, F and Bendahl, P-O and Fernö, Mårten and Liljegren, G and Emdin, S and Malmström, Per}},
  issn         = {{1569-8041}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{2284--2291}},
  publisher    = {{Oxford University Press}},
  series       = {{Annals of Oncology}},
  title        = {{A prospective, multicenter validation study of a prognostic index composed of S-phase fraction, progesterone receptor status, and tumour size predicts survival in node-negative breast cancer patients: NNBC, the node-negative breast cancer trial.}},
  url          = {{http://dx.doi.org/10.1093/annonc/mdt186}},
  doi          = {{10.1093/annonc/mdt186}},
  volume       = {{24}},
  year         = {{2013}},
}